Obstructive sleep apnea (OSA) is a heterogeneous disease with a wide spectrum and diversity. Impact of OSA is multi-systemic with predisposition to cardiac, neurological, metabolic, endocrinological, neurocognitive, and psychiatric disorders. The continuous positive airway pressure (CPAP) device has a strong recommendation in treatment of OSA. Of the patients prescribed CPAP, 5–50% are nonadherent. Various patient-, clinician-, and therapy-related barriers affect CPAP adherence. Continuous positive airway pressure adherence can be improved by focusing on the multidisciplinary aspects like (1) education and counseling, (2) intensive patient support, (3) behavioral interventions, (4) spousal collaboration, (5) machine- and interface-related issues, (6) conservative measures, (7) and newer adherence monitors. Thus providing holistic management in OSA.
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