Being one of the most pervasive disorder with far-reaching adverse health implications, understanding the etiology of obstructive sleep apnea (OSA) in relation to craniofacial morphology and malocclusion is critical with regards to rational treatment planning, management, and long-term stability. The principal aim of this article is to present an invaluable insight into the role of malocclusion in the genesis of OSA by reviewing the orthodontic and sleep medicine literature pertaining to pediatric and adult OSA populations. The potential mechanisms underlying the association of malocclusion and OSA are also discussed.
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