Indian Journal of Sleep Medicine

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VOLUME 9 , ISSUE 4 ( October-December, 2014 ) > List of Articles


Bronchial asthma and obstructive sleep apnea hypopnea syndrome: Another overlap or mere coincidence

Deepak Talwar

Keywords : Bronchialasthma, Obstructive sleep apnea hypopnea syndrome, Continuous positive airway pressure, Gastroesophageal reflux disease

Citation Information : Talwar D. Bronchial asthma and obstructive sleep apnea hypopnea syndrome: Another overlap or mere coincidence. Indian Sleep Med 2014; 9 (4):155-160.

DOI: 10.5958/0974-0155.2015.00001.7

License: NA

Published Online: 01-06-2018

Copyright Statement:  NA


Both obstructive sleep apnea and bronchial asthma are diseases associated with systemic inflammation. The patho-physiology of both these diseases is interlinked and multiple links have been elucidated between their development. How, the development of one of these diseases leads to the worsening of the other one, is poorly understood. This overlap, deserves further research and guidelines need to be crystallized for the management of this condition, as delay in diagnosis and treatment is associated with an adverse outcome.

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  1. Fitzpatrick MF, Engleman H, Whyte KF, Deary IJ, Shapiro CM, Douglas NJ. Morbidity in nocturnal asthma: sleep quality and daytime cognitive performance. Thorax1991;46:569– 573.
  2. Gislason T, Almqvist M. Somatic diseases and sleep complaints. Acta Med Scand1987;221:475–481.
  3. Janson C, Gislason T, Boman G, Hetta J, Roos BE. Sleep disturbances in patients with asthma. Respir Med 1990;84:37–42.
  4. Teodorescu M, Consens FB, Bria WF, Coffey MJ, McMorris MS, Weatherwax KJ, et al. Predictors of habitual snoring and obstructive sleepapnea risk in patients with asthma. Chest 2009;135(5):1125–1132.
  5. Knuiman M, James A, Divitini M, Bartholomew H. Longitudinal study of risk factors for habitualsnoring in a general adult population: the BusseltonHealth Study. Chest 2006;130(6):1779–1783.
  6. Teodorescu M, Barnet JH, Hagen EW, Palta M, Young TB, Peppard PE. Association between asthma and risk of developing obstructive sleep apnea. JAMA 2015; 313(2):156–164.
  7. Julien JY, Martin JG, Ernst P, Olivenstein R, Hamid Q, Lemière C, et al. Prevalence of obstructive sleep apnea– hypopnea in severe vsmoderate asthma. J Allergy Clin Immunol 2009;124(2):371–376.
  8. Reid MB, LännergrenJ, Westerblad H. Respiratory and limb muscle weakness induced by tumor necrosis factor-á: involvement of muscle myofilaments. Am J Respir Crit Care Med 2002;166(4):479–484.
  9. Van de Graaff WB. Thoracic influence on upperairway patency. J Appl Physiol1985;65:2124–2131.
  10. Teodorescu M, Xie A, Sorkness CA, Robbins J, Reeder S, Gong Y, et al. Effectsof inhaled fluticasone on upper airway during sleepandwakefulness in asthma: a pilot study. J Clin Sleep Med 2014;10(2):183–193.
  11. Emilsson OI, Bengtsson A, Franklin KA, Torén K, Benediktsdóttir B, Farkhooy A, et al. Nocturnalgastroesophageal reflux, asthma, andsymptoms of obstructive sleep apnoea: a longitudinal, general population study. Eur RespirJ 2013;41(6):1347–1354.
  12. Thomson CC, Clark S, Camargo CA Jr. Body mass index and asthma severity among adults presenting to the emergency department. Chest 2003;124:795 802.
  13. Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004;125:2046 2052.
  14. Devouassoux G, Levy P, Rossini E, Pin I, Fior-Gozlan M, Henry M, et al. Sleep apnea is associated with bronchial inflammation and continuous positive airway pressureinduced airway hyperresponsiveness. J Allergy Clin Immunol2007;119:597–603.
  15. Teramoto S, Yamamoto H, Ouchi Y. Increased C-reactive proteinand increased plasma interleukin-6 may synergistically affect the progression of coronary atherosclerosis in obstructive sleep apneasyndrome. Circulation 2003;107:E40.
  16. Schulz R, Hummel C, Heinemann S, Seeger W, Grimminger F. Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia. Am J Respir Crit Care Med 2002;165:67 70.
  17. Ing AJ, Ngu MC, Breslin AB. Obstructive sleep apnea and gastroesophageal reflux. Am J Med 2000;108(Suppl 4a):120S–125S.
  18. Avidan B, Sonnenberg A, Schnell TG, Sontag SJ. Temporal associations between coughing or wheezing and acid reflux in asthmatics. Gut 2001;49:767–772.
  19. Expert Panel Report 3: Guidelines for the diagnosis and management of asthma. Full Report 2007. Availableat: www.nhlbi.
  20. Morrison JF, Pearson SB, Dean HG. Parasympathetic nervous system in nocturnal asthma. BMJ 1988;296:1427–1429.
  21. Nadel JA Widdicombe JG. Reflex effects of upper airway irritation on total lung resistance and blood pressure. J Appl Physiol 1962;17:861–865.
  22. Desjardin JA, Sutarik JM, Suh, BY, Ballard RD. Influence of sleep on pulmonary capillary volume in normal and asthmatic subjects. Am J Respir Crit Care Med 1995;152:193–198.
  23. Nakayama K. Surgical removal of the carotid body for bronchial asthma. Chest 1961;40:595–604.
  24. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292 295.
  25. Tatsumi K, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Kuriyama T. Sleep oxygen desaturation and circulating leptin in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127:716 721.
  26. Brunnee T, Graf K, Kastens B, Fleck E, Kunkel G. Bronchial hyperreactivity in patients with moderate pulmonary circulation overload. Chest 1993;103:1477 1481.
  27. Borst MM, Beuthien W, Schwencke C, LaRosée P, Marquetant R, Haass M, et al. Desensitization of the pulmonary adenylyl cyclasesystem: a cause of airway hyperresponsiveness in congestive heart failure? J Am Col Cardiol1999;34:848 856.
  28. Levin ER. Endothelins. N Engl J Med 1995;333:356 363.
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