Citation Information :
Bhattacharyya P, Paul R, Dey R, Barooah N, Nag S, Maji S. Prevalence of left ventricular diastolic dysfunction in OSA patients: a retrospective study. Indian Sleep Med 2011; 6 (2):50-53.
Introduction: OSA has been increasingly implicated in the initiation and progression of cardiovascular diseases. We attempted to find the association of LVDD with OSA in terms of its frequency as well as in terms of several important parameters.
Materials and methods: It was a retrospective study where 32 OSA patients diagnosed by polysomnography who also underwent echocardiography were looked for the presence of LVDD. The patients were divided into two groups based on the presence or absence of LVDD and compared them according to different parameters.
Results: The overall prevalence of LVDD in our OSA patients has been found to be 46.8%. There has been found to be no significant differences as per the different parameters considered. On the contrary, severity of sleep apnea was found to be higher in the non LVDD group tallying to their higher BMI, higher neck and waist circumference.
Conclusion: It has not been possible to associate severity of OSA with risk or prevalence of LVDD as there has been found to be no difference between the two groups, with and without LVDD. This area needs further probing so as to look into the origin of LVDD in certain OSA sufferers.
Naughton MT. The link between obstructive sleep apnea and heart failure: underappreciated opportunity for treatment. Curr Cardiol Rep 2005;7:211-5
Hung J, Whitford EG, Parsons RW, Hillman DR. Association of sleep apnea with myocardial infarction in men. Lancet 1990;336:261–4.
Bradley TD. Right and left ventricular functional impairment and sleep apnea. Clin Chest Med 1992;13:459–79.
Yip G, Ho P, Woo KS, et al. Comparison of frequencies of left ventricular systolic and diastolic heart failure in Chinese living in Hong Kong. Am J Cardiol 1999;84:563–7
Alchanatis M, Paradellis G, Pini H, et al. Left ventricular function in patients with obstructive sleep apnoea syndrome before and after treatment with nasal continuous positive airway pressure. Respiration 2000; 67:367–371.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230 –1235.
Ip MS, Lam B, Lauder I, et al. A community study of sleepdisordered breathing in middle-aged Chinese men in Hong Kong. Chest 2001;119:62–69
Peker Y, Hedner J, Norum J Kraiczi H, Carlson J. Increased incidence of cardiovascular disease in middle-aged men with obstructive sleep apnea: a 7-year follow-up. Am J Respir Crit Care Med 2002; 166: 159-65.
Hung J, Whitford EG, Parsons RW, Hillman DR. Association of sleep apnea with myocardial infarction in men. Lancet 1990;336:261–4.
Bradley TD. Right and left ventricular functional impairment and sleep apnea. Clin Chest Med 1992; 13: 459–79.
Fung JW, Li TS, Choy DK, Yip GW et al. Severe obstructive sleep apnea is associated with left ventricular diastolic dysfunction. Chest 2002;121:422-29.
Sidana J, Aronow WS, Ravipati G, Stante BD, McClung JA, Belkin RN, et al. Prevalence of moderate and severe left ventricular diastolic dysfunction in obese persons with obstructive sleep apnea. Cardiology 2005;104:107-9.
Hedner J, Ejnell H, Caidahl K. Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnea. J Hypertens 1990;8:941-6.
Noda A, Okada T, Yasuma F, Nakashima N, Yokota M. Cardiac hypertrophy in obstructive sleep apnea syndrome. Chest1995;107:1538–44.
Funk GC, Lang I, Schenk P, Valipour A, Hartis S, Burghuber OC. Left ventricular diastolic dysfunction in patients with COPD in the presence and absence of elevated pulmonary arterial pressure. Chest 2008;133:1354-9.
