Sleepy Heart and Hearty Sleep: Sleep Disorders and Cardiovascular Diseases
V. Gopichandran, S. Suganya, K. P. Misra
Citation Information :
Gopichandran V, Suganya S, Misra KP. Sleepy Heart and Hearty Sleep: Sleep Disorders and Cardiovascular Diseases. Indian Sleep Med 2006; 1 (3):141-144.
Sleep is an active, energizing and blissful activity, which everybody enjoys. Diseases affecting any system of the body can alter sleep and sleep disorders can lead to problems in multiple systems of the body. Much research is going on in the field of sleep medicine and its effects on health. The association between sleep disorders and cardiovascular diseases is well known. Obstructive Sleep Apnea (OSA) is known to cause ischemic heart disease and other related cardiovascular diseases. Severe heart diseases like congestive heart failure also are known to produce sleep disordered breathing. Relationship of cardiovascular diseases to certain phases of the sleep cycles has also been reported. There is a definite need for physicians, cardiologists and sleep specialists to work together in this field of sleep disorders and cardiovascular diseases in order to improve detection and management of these conditions.
Verrier R: Sleep-related cardiovascular risk. In Kryger M, Roth T, Dement WC: Principles and Practice of Sleep Medicine. 4th ed. Philadelphia, WB Saunders, 2004
Peled N, Greenberg A, Pillar G, et al. Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in obstructive sleep apnea syndrome. Am J Hypertens 1998; 11:1284–1289.
Ip M.S., Tse H.F., Lam B. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med (2004) 169: pp 348-353.
Lavie L, Perelman A, Lavie P. Plasma homocysteine levels in obstructive sleep apnea: association with cardiovascular morbidity. Chest 2001; 120:900–908
Dugovskaya L, Lavie L, et al. Activation of oxidative metabolism and CD64 and CD11c expression in peripheral blood monocytes and neutrophils in obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2002; 165:934– 939
C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension 2004; 44:6–11
von Kanel R., Dimsdale J.E., Hemostatic alterations in patients with obstructive sleep apnea and the implications for cardiovascular disease. Chest (2003) 124 : 1956- 1967.
Ip M.S., Lam B., Ng M.M.. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med (2002) 165: 670-676.
Association of sleepdisordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000 Apr 12;283(14):1829-36.
Am J Respir Crit Care Med 159:461–467, 1999.
Redline S, Adams N, Strauss ME, et al: Improvement of mild sleep-disordered breathing with CPAP compared with conservative therapy. Am J Respir Crit Care Med 157:858– 865, 1998.
Faccenda JF, Mackay TW, Boon NA, Douglas NJ: Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apneahypopnea syndrome. Am J Respir Crit Care Med 163:344– 348, 2001.
Javaheri S, Parker TJ, Liming JD, et al: Sleep apnea in 81 ambulatory male patients with stable heart failure: Types and their prevalences, consequences, and presentations. Circulation 97:2154–2159, 1998.
Javaheri S: A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 341:949–954, 1999.
Bradley TD, Logan AG, Kimoff RJ et al. Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure. N Engl J Med. 2005 Nov 10;353(19):2025-33.
