Complex sleep apnea is increasingly recognized as an emerging entity with improved awareness and treatment of obstructive sleep apnea (OSA). This condition may cause continuous positive airway pressure (CPAP) intolerance and persistent symptoms of sleepiness. An high index of suspicion is required to diagnose these subset of patients both during titration and on CPAP therapy. Early recognition of the condition and institution of proper treatment and follow-up measure will improve the CPAP therapy in OSA.
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