Indian Journal of Sleep Medicine

Register      Login

VOLUME 9 , ISSUE 1 ( January-March, 2014 ) > List of Articles

REVIEW ARTICLE

Phototherapy: Role in Sleep Disorders

Preeti Devnani

Keywords : Circadian rhythm disorders, phototherapy, circadian rhythm and diabetes, seasonal affective disorders.

Citation Information : Devnani P. Phototherapy: Role in Sleep Disorders. Indian Sleep Med 2014; 9 (1):1-6.

DOI: 10.5958/0974-0155.2014.01098.5

License: CC BY-SA 4.0

Published Online: 01-03-2014

Copyright Statement:  Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

In the natural world, the light/dark cycle entrains our rhythm. Light is a very effective “zeitgeber.” In the presence of environmental time cues, sleep–wake physiology and gene expression continue to exhibit a near-24-hour circadian rhythm regulated by the suprachiasmatic nucleus in the hypothalamus. Phototherapy is an accepted modality for the non-pharmacological management of circadian disorders, such as delayed sleep phase syndrome, insomnia, and mood disorders. This review discusses the clinical repercussions of circadian rhythm disorders, the physiological principle of phototherapy, and its application across the spectrum of sleep disorders.


PDF Share
  1. Srinivasan V. Melatonin, biological rhythm disorders and phototherapy. Indian J Physiol Pharmacol 1997;41(4):309– 328.
  2. Shechter A, Boivin DB. Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder. Int J Endocrinol 2010;2010:259345.
  3. Parry BL. Jet lag: Minimizing it's effects with critically timed bright light and melatonin administration. J Mol Microbiol Biotechnol 2002;4(5):463–466.
  4. Rakshit K, Thomas AP, Matveyenko AV. Does Disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Curr Diab Rep 2014;14(4):474.
  5. Reutrakul S, Van Cauter E. Interactions between sleep, circadian function, and glucose metabolism: Implications for risk and severity of diabetes. Ann N Y Acad Sci 2014;1311:151–173.
  6. Takagi T, Inada Y, Naito Y. [Circadian rhythm and inflammatory bowel disease.] Nihon Rinsho 2013;71(12):2165–2170.
  7. Voigt RM, Forsyth CB, Green SJ, et al. Circadian disorganization alters intestinal microbiota. PLoS One 2014;9(5):e97500.
  8. Czeisler CA, Shanahan TL, Klerman EB, et al. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 1995;332:6–11.
  9. Lange T, Dimitrov S, Born J. Effects of sleep and circadian rhythm on the human immune system. Ann N Y Acad Sci 2010;1193:48–59.
  10. Terman M, Terman JS. Light therapy for seasonal and nonseasonal depression: Efficacy, protocol, safety, and side effects. CNS Spectr 2005;10(8):647–663.
  11. Tamrat R, Huynh-Le MP, Goyal M. Non-pharmacologic interventions to improve the sleep of hospitalized patients: A systematic review. J Gen Intern Med 2014;29(5):788– 795.
  12. Chesson AL, Littner M, Davila D, et al. Practice parameters for the use of light therapy in the treatment of sleep disorders. Sleep 1999;22:641–660.
  13. Rosenthal NE, Joseph-Vanderpool JR, Levendosky AA, et al. Phase-shifting effects of bright morning light as treatment for delayed sleep phase syndrome. Sleep 1990;13(4):354– 361.
  14. Paul MA, Gray JW, Lieberman HR, et al. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl) 2011;214(2):515–523.
  15. Stewart KT, Hayes BC, Eastman CI. Light treatment for NASA shiftworkers. Chronobiol Int 1995;12(2):141–151.
  16. Yoon IY, Jeong DU, Kwon KB, Kang SB, Song BG. Bright light exposure at night and light attenuation in the morning improve adaptation of night shift workers. Sleep 2002;25(3):351–356.
  17. Khachiyants N, Trinkle D, Son SJ, Kim KY. Sundown syndrome in persons with dementia: An update. Psychiatry Investig 2011;8:275–287.
  18. Satlin A, Volicer L, Ross V, Herz L, Campbell S. Bright light treatment of behavioral and sleep disturbances in patients with Alzheimer's disease. Am J Psychiatry 1992;149(8):1028–1032.
  19. Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C. Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression. J Clin Psychiatry 2014;75(2):133–140.
  20. Prasko J, Brunovsky M, Latalova K, et al. Augmentation of antidepressants with bright light therapy in patients with comorbid depression and borderline personality disorder. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2010;154(4):355–361.
  21. Thompson C, Childs PA, Martin NJ, Rodin I, Smythe PJ. Effects of morning phototherapy on circadian markers in seasonal affective disorder. Br J Psychiatry 1997;170:431–435.
  22. Gloth FM, Alam W, Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 1999;3(1):5–7.
  23. Rybak YE, McNeely HE, Mackenzie BE, Jain UR, Levitan RD. An open trial of light therapy in adult attention-deficit/ hyperactivity disorder. J Clin Psychiatry 2006;67(10):1527– 1535.
  24. Most EI, Scheltens P, Van Someren EJ. Prevention of depression and sleep disturbances in elderly with memoryproblems by activation of the biological clock with light-a randomized clinical trial. Trials 2010;11:19.
  25. Terman M, Terman JS. Bright light therapy: Side effects and benefits across the symptom spectrum. J Clin Psychiatry 1999;60(11):799–808.
  26. Botanov Y, Ilardi SS. The acute side effects of bright light therapy: A placebo-controlled investigation. PLoS One 2013;8(9):e75893.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.