Obesity is recognized as one of the predominant risk factor for Obstructive Sleep Apnea (OSA). Even moderate reduction in weight and body mass index (BMI) could reduce the severity of OSA and is recommended as part of comprehensive therapeutic approach in patients who are prescribed Positive Airway Pressure (PAP) therapy. However, this remains a challenge for most patients and some may even report weight gain. In this article, we report a case history highlighting weight gain while on PAP therapy and review the literature on this phenomenon.
Surendra K. Sharma, Swastik Agarwal, Deepak Damodaran, et al. CPAP for the metabolic syndrome in patients with obstructive sleep apnea. N Engl J Med. 2011 Dec 15; 365:2277-86.
Gami AS, Caples SM, Somers VK. Obesity and obstructive sleep apnea. Endocrinol Metab Clin North Am 2003; 32: 869-94.
Vijay Viswanathan, N Ramakrishnan, S Sunaina, et al. Subjects with Type 2 Diabetes may have Obstructive Sleep Apnea even at lower BMI values. Indian J Sleep Med 2012; 7.2: 45-47.
Chin K, Shimizu K, Nakamura T, et al. Changes in intraabdomi- nal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999; 100:706-12.
Cuhadaroglu C, Utkusavas A, Ozturk L, Salman S, Ece T: Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. Lung 2009, 187(2):75-81.
Rachel Redenius,Carli Murphy, Erin O'Neill, Majed Al- Hamwi, Sarah Nath Zallek. Does CPAP Lead to Change in BMI? J Clin Sleep Med. 2008 June 15; 4(3): 205–209.
Stenlof K, Grunstein R, Hedner J, Sjostrom L. Energy expendi-ture in obstructive sleep apnea: effects of treatment with continu-ous positive airway pressure. Am J Physiol 1996; 271:E1036-43.
Harsch IA, Konturek PC, Koebnick C, et al. Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. Eur Respir J 2003; 22:251-7.
Anas Balaa, Ahmed M. Abugiazya, Raymond Bourey. Early gain in body mass with continuous positive airway pressure therapy for obstructive apnea. Chest. 2009; 136(4_MeetingAbstracts):70S. Doi: Abstract / October 2009.
Amarbir Mattewal, Supriya Singh, Max Hirshkowitz, Amir Sharafkhaneh et al Effect of Continuous Positive Airway Pressure (CPAP) Therapy on Weight in Patients with Obstructive Sleep Apnea (OSA)-A Record Review Study. Chest 2011;140(4_MeetingAbstracts):1070A. doi:10.1378/chest.1119750.
Jose M Garcia, Hossein Sharafkhaneh, Max Hirshkowitz, Rania Elkhatib and Amir Sharafkhaneh. Weight and metabolic effects of cpap in obstructive sleep apnea patients with obesity. Respiratory Research 2011, 12:80.
Borel AL, Leblanc X, Almeras N, et al. Sleep apnoea attenuates the effects of a lifestyle intervention programme in men with visceral obesity. Thorax. 2012 Aug; 67(8):735-41. 10.