The case of a 74 years old hypertensive and obese lady is reported. She had repeated hospitalizations following episodes of left ventricular failure A polysomnographic study confirmed the diagnosis of obesity hypoventilation syndrome. This condition is briefly reviewed.
Berry R. Noninvasive positive pressure ventilation and treatment initiation for chronic hypoventilation syndromes. Sleep Med Clin 5 (2010) 485-505
Chang CL, Marshall N.S, Yee B.J., Grunstein R.R. Weightloss treatment for OSA: medical and surgical options. Eur Respir Mon 2010; 50, 302–320.
Norman RG, Goldring RM, Clain JM, Oppenheimer BW, Charney AN, Rapoport DM, et al. Transition from acute to chronic hypercapnia in patients with periodic breathing: predictions from a computer model. J Appl Physiol 2006; 100(5):1733-1741.
Han F, Chen E, Wei H, He Q, Ding D, Strohl KP. Treatment effects on carbon dioxide retention in patients with obstructive sleep apnea-hypopnea syndrome. Chest 2001; 119(6)1814-1819.
Berthon-Jones M, Sullivan CE. Time course of change in ventilatory response to CO2 with long-term CPAP therapy for obstructive sleep apnea. Am Rev Respir Dis 1987; 135(1):144-147.
Lin CC. Effect of nasal CPAP on ventilatory drive in normocapnic and hypercapnic patients with obstructive sleep apnoea syndrome. Eur Respir J 1994; 7(11):2005- 2010.
Ip MS, Lam KS, Ho C, Tsang KW, Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000; 118(3):580-586.
Barcelo A, Barbe F, Llompart E, de la Pena M, Duran- Cantolla J, Ladaria A, et al. Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity. Am J Respir Crit Care Med 2005;171(2):183-187.
Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005; 127(2):543-549.
Makinodan K, Yoshikawa M, Fukuoka A, Tamaki S, Koyama N, Yamauchi M, et al. Effect of serum leptin levels on hypercapnic ventilatory response in obstructive sleep apnea. Respiration 2008; 75(3):257-264.