Indian Journal of Sleep Medicine

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VOLUME 5 , ISSUE 2 ( April-June, 2010 ) > List of Articles


Familial aggregation of sleep disorders – a questionnaire based study

Tulsi Adhikari, M K Sen, J. C. Suri

Citation Information : Adhikari T, Sen MK, Suri JC. Familial aggregation of sleep disorders – a questionnaire based study. Indian Sleep Med 2010; 5 (2):50-53.

DOI: 10.5005/ijsm-5-2-50

License: NA

Published Online: 01-07-2018

Copyright Statement:  NA


A questionnaire-based study was performed amongst schoolchildren of Delhi and their first degree relatives to assess the sleep patterns. 2475 subjects were finally selected for analysis. It was observed that 10.8% of the children who had bruxism had no familial linkage. Whereas 42.6% of them also had a sibling who had bruxism, 44.4% had either one/both parents along with one/both grandparents with the disorder. In the case of snoring, 5.6% had no familial linkage, 45.5%, 9.7% and 7.5% had a linkage with siblings, parents/grandparents and parents as well as grandparents respectively. It can be inferred from these observations of the present study that the prevalence of most sleep disorders was the least in those children who had no familial linkage of the condition at all. The results of this study emphasize the urgent need to conduct more extensive genetic analyses to establish the causative factors, if any.

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  1. Strohl KP, Saunders NA, Feldman NT, Hallett M. Obstructive sleep apnea in family members. N Engl J Med 1978; 299:969-973.
  2. Bayadi SE, Millman RP, Tishler PV et al. A family study of sleep apnea. Hum Genet 1986; 73:39-43.
  3. Health AC, Kendler KS, Eares LJ, Martin NG. Evidence for genetic influences on sleep disturbance and sleep patterns in twins. Sleep 1990; 13:318-335.
  4. Guilleminault C, Partinen M, Hollman K, Powell N, Stoohs R. Familial aggregates in obstructive sleep apnea syndrome. Chest 1995; 107:1545-1551.
  5. Dauvillers Y, Tafti M. The genetic basis of sleep disorders. Curr Pharm Des 2008; 14(32):3386-3395.
  6. Winkelmann J. Genetics of restless legs syndrome. Curr Neurol Neurosci Rep 2008;8(3):211-216.
  7. Adel S, Djarmati A, Kabakci K, Pichler I, Eskelson C, Lohnau T, Kock N, Hagenah J, Hedrich K, Schwinger E, Kramer PL, Pramstaller PP, Klein C. Co-occurrence of restless legs syndrome and Parkin mutations in two families. Mov Disord 2006; 21(2):258-263.
  8. Xiong L, Montplasir J, Desautels A, Barhdadi A, Turecki G, Levchenko A, Thibodeau P, Dube MP, Gaspar C, Rouleau GA. Family study of restless legs syndrome in Quebec, Canada: Clinical characterization of 671 familial cases. Arch Neurol 2010; 67(5):617-622.
  9. Gaultier C. Obstructive sleep apnea syndrome and genetics. Rev Neurol (Paris) 2003; 159:6S98-101.
  10. Young T, Palta M, Dempsey J et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993; 328:1230-1235.
  11. Ovichivsky A, Rao M, Lotwin I, Goldstein NA. The familial aggregation of pediatric obstructive sleep apnea syndrome. Arch otolaryngol Head Neck Surg 2002; 128:815-818.
  12. McNamara F, Sullivan CE. Obstructive sleep apnea in infants: relation to family history of sudden infant death syndrome, apparent life threatening events, and obstructive sleep apnea. J Pediatr 2000; 136:318-323.
  13. Zhang J, Li AM, Kong AP, Lai KY, Tang NL, Wing YK. A community-based study of insomnia in Hong Kong Chinese children: Prevalence, risk factors and familial aggregation. Sleep Med 2009, 10:1040-1046.
  14. Drake CL, Scofield H, Roth T. Vulnerability to insomnia: the role of familial aggregation. Sleep Med 2008; 9:297-302.
  15. Dauvilliers Y, Morin C, Cervena K, Car Lander B, Touchon J, Besset A, Billard M. Family studies in insomnia. J Psychosom Res 2005; 58:271-278.
  16. Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I, Ferretle V, Krejci P. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995; 151:682-687.
  17. Douglas NJ, Luke M, Mathur R. Is the sleep apnea/ hypopnea syndrome inherited? Thorax 1993; 48:719-721.
  18. Holberg CJ, Natrajan S, Cline MG, Quan SF. Familial aggregation and segregation analysis of snoring and symptoms of obstructive sleep apnea. Sleep Breath 2000; 4(1):21-30.
  19. Chervin R et al. Pediatric Sleep Questionnaire, University of Michigan (
  20. Douglass AB, Bornstein R, Nino-Murcia G, Keenan S, Miles S, Zerconn VP Jr. The Sleep Disorders Questionnaire I: Creation and multivariate structure of SDQ. Sleep 1994; 17:160-167.
  21. Suri JC, Sen MK, Adhikari T. Epidemiology of sleep disorders in schoolchildren of Delhi: A questionnaire based study. Indian J Sleep Med 2008; 3.2; 42-50.
  22. Suri JC, Sen MK, Adhikari T. Epidemiology of sleep disorders in adult population of Delhi: A questionnaire based study. Indian J Sleep Med 2008; 3.4:128-137.
  23. Suri JC, Sen MK, Ojha UC, Adhikari T. Epidemiology of sleep disorders in the elderly: A questionnaire survey. Indian J Sleep Med 2009; 4.1:12-18.
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