Indian Journal of Sleep Medicine

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VOLUME 20 , ISSUE 1 ( January-March, 2025 ) > List of Articles

REVIEW ARTICLE

A Systematic Review Assessing the Impact of Surgery on Sleep Disturbances in Craniopharyngioma

Jacqueline G Nash, Peter J Davies, Pratibha Natesh

Keywords : Adamantinous, Brain tumor, Hypothalamic injury, Neurosurgery, Obstructive sleep apnea, Papillary, Pituitary, Rathke cleft

Citation Information : Nash JG, Davies PJ, Natesh P. A Systematic Review Assessing the Impact of Surgery on Sleep Disturbances in Craniopharyngioma. Indian Sleep Med 2025; 20 (1):16-29.

DOI: 10.5005/jp-journals-10069-0144

License: CC BY-NC 4.0

Published Online: 15-01-2025

Copyright Statement:  Copyright © 2025; The Author(s).


Abstract

Introduction: Craniopharyngiomas (CP) are rare benign brain tumors associated with high morbidity due to their proximity to important structures. Surgical resection is key to treatment but carries significant risk due to iatrogenic hypothalamic injury. The hypothalamus plays a vital role in the regulation of the sleep-wake cycle. Therefore, damage due to the Craniopharyngioma or surgery could result in sleep disturbances, negatively affecting health outcomes and quality of life. This systematic review aimed to evaluate sleep in patients both pre- and postsurgery to try and define the role of surgery on sleep disturbances, which may enable better management of patients by guiding surgical decision-making. Methods: A systematic review was performed using Medline, Embase, and Scopus. Inclusion criteria were articles that described sleep disturbances pre- and/or postsurgery in craniopharyngioma. Eleven studies were included. Critical appraisal showed a high risk of bias. The data extracted were unsuitable for meta-analysis, but the weighted prevalence of sleep disturbances was calculated and compared. Results: No statistical difference was found between the weighted prevalence of sleep disturbances pre- vs postsurgery. Combined findings of individual studies displayed no clear patterns of differences in sleep disturbances pre- to postsurgery. The most common sleep disturbances were excessive daytime sleepiness (EDS)/somnolence. Limitations of studies included a lack of control groups, insufficient statistical analysis, and small sample sizes. Conclusion: The findings of this review suggest that sleep disturbances are not different pre- to postsurgery. However, the strength of this conclusion is limited by the quality of the evidence included, highlighting the need for more suitably designed primary research in this area. Systematic review registration: http://www.crd.york.ac.uk/PROSPERO, identifier CRD42023469112.


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