Indian Journal of Sleep Medicine

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VOLUME 16 , ISSUE 3 ( July-September, 2021 ) > List of Articles

CASE REPORT

Preventive Effect of Lithium on “Kleine–Levin Syndrome”

Javed A Siddiqui, Shazia F Qureshi, Adel Allethey, Talal A Mahfouz

Keywords : Hyperphagia, Hypersexuality, Hypersomnia, Kleine–Levin syndrome, Lithium, Sleeping beauty

Citation Information : Siddiqui JA, Qureshi SF, Allethey A, Mahfouz TA. Preventive Effect of Lithium on “Kleine–Levin Syndrome”. Indian Sleep Med 2021; 16 (3):93-94.

DOI: 10.5005/jp-journals-10069-0078

License: CC BY-NC 4.0

Published Online: 13-10-2021

Copyright Statement:  Copyright © 2021; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Kleine–Levin syndrome (KLS) is a rare sleep disorder characterized by periodic excessive sleepiness, hyperphagia, hypersexuality, and varying degrees of cognitive and behavioral disturbances. Here, we report a typical case of Kleine–Levin syndrome associated with deterioration of academic performance because of excessive sleepiness. He was started on modafinil and lithium, to which he showed good response.


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  1. Kleine W. Periodische Schlafsucht. Mschr Psychiatr Neurol 1925;57 (5–6):285–320. DOI: 10.1159/000190426.
  2. Levin M. Periodic somnolence and morbid hunger: a new syndrome. Brain 1936;59(4):494–504. DOI: 10.1093/brain/59.4.494.
  3. Critchley M. Periodic hypersomnia and megaphagia in adolescent males. Brain 1962;85(4):627–656. DOI: 10.1093/brain/85.4.627.
  4. Murthy VS, Kelkar AD, Sonavane SS. Psychosis in a case of Kleine-Levin syndrome: a diagnostic challenge. Indian J Psychol Med 2014;36(2):192–194. DOI: 10.4103/0253-7176.130993.
  5. Merriam A. Kleine-Levin syndrome following acute viral encephalitis. Biol Psychiatry 1986;21(13):1301–1304. DOI: 10.1016/0006-3223(86)90313-6.
  6. Chesson A, Levine S, Kong LS, et al. Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence. Sleep 1991;14(3):226–232. DOI: 10.1093/sleep/14.3.226.
  7. Arnulf I, Lin L, Gadoth N, et al. Kleine-Levin syndrome: a systematic study in 108 patients. Ann Neurol 2008;63(4):482–493. DOI: 10.1002/ana.21333.
  8. Goldberg MA. The treatment of Kleine-Levin syndrome with lithium. Can J Psychiatry 1983;28(6):491–493. DOI: 10.1177/070674378302800616.
  9. Crumley FE. Valproic acid for Kleine-Levin syndrome. J Am Acad Child Adolesc Psychiatry 1997;36(7):868–869. DOI: 10.1097/00004583-199707000-00005.
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