Background: Periodontitis is a ubiquitous chronic inflammatory disease affecting the supporting structures of the teeth, and if not promptly diagnosed and correctly managed can ultimately lead to tooth loss. Sleep is a complex and essentially biological process that is required on a daily basis for all humans regardless of age, sex, or ethnic origin. Since inflammation is characteristic of both chronic periodontitis and sleep deprivation, the present study was undertaken to study the relationship between quality of sleep and chronic periodontitis. Materials and methods: A case-control study was conducted among the outpatients reporting to Asan Memorial Dental College and Hospital. The sample size for the study was n = 198. The survey comprises of demographic data of study participants followed by an interviewer administered questionnaire to assess the quality of sleep using the Pittsburgh sleep assessment scale followed by clinical assessment to record periodontal health status using community periodontal index (CPI) by WHO. Results: Patients who were sleep deprived showed increased loss of attachment from 3 to 5 mm to more than 12 mm. Odds ratio showed that patients with periodontitis had 3.36 times the risk of sleep deprivation compared to patients without periodontitis. Conclusion: Lack of good quality of sleep will be a risk factor for periodontitis.