Indian Journal of Sleep Medicine

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VOLUME 13 , ISSUE 2 ( April-June, 2018 ) > List of Articles

REVIEW ARTICLE

Sleep Disorders in Kidney Diseases

Manas K Sen

Keywords : Kidney disease, Renal Failure, Sleep apnoea

Citation Information : Sen MK. Sleep Disorders in Kidney Diseases. Indian Sleep Med 2018; 13 (2):29-35.

DOI: 10.5005/jp-journals-10069-0021

License: CC BY-SA 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Sleep disorders are common, multi-factorial and often underrecognized in patients with renal diseases. Sleep disorders have a negative impact on the wellbeing and quality of life. Medical literature in the past few years has documented many definitive associations between kidney diseases and various sleep disorders. Prompt referral to a sleep medicine specialist for further evaluation is warranted in this group of patients at the earliest suspicion of an insidious sleep disorder. In this review, we will discuss the common sleep disorders seen in patients with kidney disorders–the restless leg syndrome/Willis–Ekbom disease (RLS/WED), sleep-disordered breathing (SDB), insomnia disorder, hypersomnolence disorder, circadian rhythm sleep-wake disorders (CRSWDs) and parasomnias.


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  1. Pierratos A, Hanly PJ. Sleep disorders over the full range of chronic kidney disease. Blood Purif. 2011;31(1-3):146-150.
  2. Xu J, Yoon IY, Chin HJ. The effect of sleep apnea on all-cause mortality in nondialyzed chronic kidney disease patients. Sleep Med. 2016 Nov-Dec;27-28:32-38.
  3. Parvan K, lakdizaji S, Roshangar F, Mostofi M. Quality of Sleep and its Relationship to Quality of Life in Hemodialysis Patients. Journal of Caring Sciences. 2013 Dec;2(4):295-304.
  4. Maung SC, El Sara A, Chapman C, Cohen D, Cukor D. Sleep disorders and chronic kidney disease. World J Nephrol. 2016 May 6;5(3):224-232.
  5. Klingelhoefer L, Bhattacharya K, Reichmann H. Restless legs syndrome. Clin Med (Lond). 2016 Aug;16(4):379-382.
  6. Rinaldi F, Galbiati A, Marelli S, Cusmai M, Gasperi A, Oldani A, Zucconi M, Padovani A, Strambi LE. Defining the phenotype of restless legs syndrome/Willis-Ekbom disease (RLS/WED): a clinical and polysomnographic study. J Neurol. 2016 Jan 2;263(2):396-402.
  7. Lee J, Nicholl DDM, Ahmed SB, Loewen AHS, Hemmelgarn BR, Beecroft JM, Turin TC, Hanly PJ. The Prevalence of Restless Legs Syndrome across the Full Spectrum of Kidney Disease. Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine. 2013 May 15;9(5):455-459.
  8. Lin Z, Zhao C, Luo Q, Xia X, Yu X, Huang F. Prevalence of restless legs syndrome in chronic kidney disease: a systematic review and meta-analysis of observational studies. Ren Fail. 2016 Oct 20;38(9):1335-1346.
  9. Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor Other Hyperkinet Mov (N Y). 2016 Jul;6:401.
  10. Allen RP. Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology. Sleep Medicine Clinics. 2015 Sep;10(3):207- 214.
  11. Gigli GL, Adorati M, Dolso P, Piani A, Valente M, Brotini S. Restless legs syndrome in end-stage renal disease. Sleep Med. 2004 May;5(3):309-315.
  12. Kavanagh D, Siddiqui S, Geddes CC. Restless legs syndrome in patients on dialysis. Am J Kidney Dis. 2004 May 1;43(5):763-771.
  13. Beladi-Mousavi SS, Jafarizade M, Shayanpour S, Bahadoram M, Moosavian SM, Houshmand G. Restless Legs Syndrome: Associated Risk Factors in Hemodialysis Patients. Nephrourol Mon. 2015 Nov 29;7(6):e31967.
  14. Schmid G, Bahner U, Peschkes J, Heidland A. Neurotransmitter and monoaminergic amino acid precursor levels in rat brain: effects of chronic renal failure and of malnutrition. Miner Electrolyte Metab. 1996;22(1-3):115-118.
  15. Mortazavi M, Vahdatpour B, Ghasempour A, Taheri D, Shahidi S, Moeinzadeh F, Dolatkhah B, Dolatkhah S. Aerobic exercise improves signs of restless leg syndrome in end stage renal disease patients suffering chronic hemodialysis. ScientificWorldJournal. 2013 Nov 6;2013:628142.
  16. Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003 Mar;4(2):101-119.
  17. Carlos K, Prado GF, Teixeira CD, Conti C, de Oliveira MM, Prado LB, et al. Benzodiazepines for restless legs syndrome. Cochrane Database Syst Rev. 2017 Mar 20;3:CD006939.
  18. Jaber BL, Schiller B, Burkart JM, Daoui R, Kraus MA, Lee Y, Milar BM, Teitel Baum I, Williams AW, Finkelstei FO, Impact of short daily hemodialysis on restless legs symptoms and sleep disturbances. Clin J Am Soc Nephrol. 2011 May;6(5):1049-1056.
  19. Azar SA, Hatefi R, Talebi M. Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplant Proc. 2007 May;39(4):1132-1133.
  20. Winkelmann J, Stautner A, Samtleben W, Trenkwalder C. Long-term course of restless legs syndrome in dialysis patients after kidney transplantation. Mov Disord. 2002 Sep;17(5):1072-1076.
  21. Dou L, Lan H, Reynolds DJ, Gunderson TM, Kashyap R, Gajic O, Caples S, Li G, Kashani JB. Association between Obstructive Sleep Apnea and Acute Kidney Injury in Critically Ill Patients: A Propensity-Matched Study. Nephron. 2017;135(2):137-146.
  22. Lin YS, Liu PH, Lin SW, Chuang LP, Ho WJ, Chou YT, et al. Simple obstructive sleep apnea patients without hypertension or diabetes accelerate kidney dysfunction: a population follow-up cohort study from Taiwan. Sleep Breath. 2017 Mar;21(1):85-91.
  23. Fu Q, Colgan SP, Shelley CS. Hypoxia: The Force that Drives Chronic Kidney Disease. Clin Med Res. 2016 Mar;14(1):15- 39.
  24. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230- 1235.
  25. Wali SO, Alkhouli A, Howladar M, Ahmad I, Alshohaib S, Al-Ghamdi S, Kayem A. Risk of obstructive sleep apnea among Saudis with chronic renal failure on hemodialysis. Ann Thorac Med. 2015 Oct-Dec;10(4):263-268.
  26. Nicholl DD, Ahmed SB, Loewen AH, Hemmelgarn BR, Sola DY, Beecroft JM, Turin TC, Henly PJ. Diagnostic value of screening instruments for identifying obstructive sleep apnea in kidney failure. J Clin Sleep Med. 2013 Jan 15;9(1):31- 38.
  27. Al-Jahdali H. Prevalence of sleep apnea and excessive day time sleepiness in patients with end-stage renal disease on dialysis. Saudi J Kidney Dis Transpl. 2012 Mar 1;23(2):251- 261.
  28. Ezzat H, Mohab A. Prevalence of sleep disorders among ESRD patients. Ren Fail. 2015 Jul 3;37(6):1013-1019.
  29. Huang HC, Walters G, Talaulikar G, Figurski D, Carroll A, Hurwitz M, Karte K, Singer R. Sleep apnea prevalence in chronic kidney disease - association with total body water and symptoms. BMC Nephrol. 2017 Apr 4;18(1):125.
  30. Elias RM, Bradley TD, Kasai T, Motwani SS, Chan CT. Rostral overnight fluid shift in end-stage renal disease: relationship with obstructive sleep apnea. Nephrology Dialysis Transplantation. 2011 Nov 5;27(4):1569-73.
  31. Elias RM, Chan CT, Paul N, Motwani SS, Kasai T, Gabriel JM, Spiller N, Bradely TD. Relationship of pharyngeal water content and jugular volume with severity of obstructive sleep apnea in renal failure. Nephrol Dial Transplant. 2013 Apr;28(4):937-944.
  32. Spicuzza L, Caruso D, Di Maria G. Obstructive sleep apnoea syndrome and its management. Therapeutic Advances in Chronic Disease. 2015 Sep;6(5):273-285.
  33. Beecroft JM, Hoffstein V, Pierratos A, Chan CT, McFarlane P, Hanly PJ. Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea and end-stage renal disease. Nephrol Dial Transplant. 2008 Feb;23(2):673- 679.
  34. Tang SC, Lam B, Lam JC, Chan CK, Chow CC, Ho YW, Ip MS, Lai KN. Impact of nephrotic edema of the lower limbs on obstructive sleep apnea: gathering a unifying concept for the pathogenetic role of nocturnal rostral fluid shift. Nephrology Dialysis Transplantation. 2012 Jan 16;27(7):2788-94.
  35. Lee JJ, Kim GS, Kim JA, Kim SJ, Kang JG, Kim GH, Jung HH. Improvement of sleep-related breathing disorder in patients with end-stage renal disease after kidney transplantation. Clin Transplant. 2011 Jan-Feb;25(1):126-130.
  36. Muza RT. Central sleep apnoea—a clinical review. Journal of Thoracic Disease. 2015 May;7(5):930-937.
  37. Nigam G, Pathak C, Riaz M. A systematic review of central sleep apnea in adult patients with chronic kidney disease. Sleep Breath. 2016 Sep 1;20(3):957-964.
  38. Nigam G, Riaz M. Probing the prevalence of central sleep apnea in patients with chronic kidney disease. Sleep Breath. 2016 Dec 1;20(4):1275-1276.
  39. Fleischmann G, Fillafer G, Matterer H, Skrabal F, Kotanko P. Prevalence of chronic kidney disease in patients with suspected sleep apnoea. Nephrol Dial Transplant. 2010 Jan;25(1):181-186.
  40. Nigam G, Riaz M. Pathophysiology of central sleep apnea in chronic kidney disease. Saudi J Kidney Dis Transpl. 2016 Sep 1;27(5):1068-70.
  41. Hanly PJ, Pierratos A. Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis. N Engl J Med. 2001 Jan 11;344(2):102-107.
  42. Diagnostic and statistical manual of mental disorders : DSM-IV: Fourth edition. Washington, DC : American Psychiatric Association, 1994.
  43. Gupta R, Zalai D, Spence DW, BaHammam AS, Ramasubramanian C, Monti JM, Pandi-Perumal SR. When insomnia is not just insomnia: the deeper correlates of disturbed sleep with reference to DSM-5. Asian J Psychiatr. 2014 Dec;12:23- 30.
  44. Diagnostic and statistical manual of mental disorders : DSM-5: Fifth edition. Arlington, VA : American Psychiatric Publishing, 2013.
  45. Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG, Espie CA, Garcia-Borreguero A, Gjerstad M, Gonclaves et al. European guideline for the diagnosis and treatment of insomnia. J Sleep Res. 2017 Dec;26(6):675- 700.
  46. Sabbatini M, Minale B, Crispo A, Pisani A, Ragosta A, Esposito R, et al. Insomnia in maintenance haemodialysis patients. Nephrol Dial Transplant. 2002 May 1;17(5):852-856.
  47. Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M, et al. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant. 2006 Jan;21(1):184-190.
  48. Ibrahim JM, Wegdan OM. Epidemiology of sleep disorders in patients with chronic renal disease in Cairo, Egypt. J Egypt Public Health Assoc. 2011 Aug;86(3-4):68-72.
  49. Lin HY, Hung CC, Chang YH, Lin MY, Yang MY, Liang SS, Liu W, Chen HC, Hwang SJ. Nonapnea Sleep Disorders in Patients Younger than 65 Years Are Significantly Associated with CKD: A Nationwide Population-Based Study. PLoS One. 2015 Oct 14;10(10):e0140401.
  50. Kosmadakis GC, Medcalf JF. Sleep disorders in dialysis patients. Int J Artif Organs. 2008 Nov;31(11):919-927.
  51. Knezevic MZ, Djordjevic VV, Jankovic SM, Djordjevic VM. Influence of dialysis modality and membrane flux on insomnia severity in haemodialysis patients. Nephrology (Carlton). 2013 Nov;18(11):706-711.
  52. Sugimoto T, Nagake Y, Sugimoto S, Akagi S, Ichikawa H, Nakamura Y, Ogawar N, Makio H. Plasma Orexin Concentrations in Patients on Hemodialysis. Nephron. 2002;90(4):379-383.
  53. Rayner HC. Orexin as a possible cause of insomnia in dialysis patients. Am J Kidney Dis. 2003 Jun 1;41(6):1335-6; author reply 6.
  54. Esposito MG, Cesare CM, De Santo RM, Cice G, Perna AF, Violetti E, Conzo G, Bilancio G, Celci S, Annunziata F et al. Parathyroidectomy improves the quality of sleep in maintenance hemodialysis patients with severe hyperparathyroidism. J Nephrol. 2008 Mar-Apr;21 Suppl 13: S92-S96.
  55. Chen HY, Chiang CK, Wang HH, Hung KY, Lee YJ, Peng YS, Wu KD, Tasi TJ. Cognitive-behavioral therapy for sleep disturbance in patients undergoing peritoneal dialysis: a pilot randomized controlled trial. Am J Kidney Dis. 2008 Aug;52(2):314-323.
  56. Shariati A, Jahani S, Hooshmand M, Khalili N. The effect of acupressure on sleep quality in hemodialysis patients. Complement Ther Med. 2012 Dec 1;20(6):417-423.
  57. Rambod M, Pourali-Mohammadi N, Pasyar N, Rafii F, Sharif F. The effect of Benson's relaxation technique on the quality of sleep of Iranian hemodialysis patients: a randomized trial. Complement Ther Med. 2013 Dec 1;21(6):577-584.
  58. Yang B, Xu J, Xue Q, Wei T, Ye C, Mei C, Mao Z. Nonpharmacological interventions for improving sleep quality in patients on dialysis: systematic review and meta-analysis. Sleep Med Rev. 2015 Oct;23:68-82.
  59. Berkowski JA, Shelgikar AV. Disorders of Excessive Daytime Sleepiness Including Narcolepsy and Idiopathic Hypersomnia. Sleep Med Clin. 2016 Sep 1;11(3):365-378.
  60. Walker S, Fine A, Kryger MH. Sleep complaints are common in a dialysis unit. Am J Kidney Dis. 1995 Nov 1;26(5):751-756.
  61. Hanly PJ, Gabor JY, Chan C, Pierratos A. Daytime sleepiness in patients with CRF: impact of nocturnal hemodialysis. Am J Kidney Dis. 2003 Feb;41(2):403-410.
  62. Parker KP, Bliwise DL, Bailey JL, Rye DB. Daytime sleepiness in stable hemodialysis patients. Am J Kidney Dis. 2003 Feb 1;41(2):394-402.
  63. Teles F, Azevedo VF, Miranda CT, Miranda MP, Teixeira Mdo C, Elias RM. Depression in hemodialysis patients: the role of dialysis shift. Clinics (Sao Paulo). 2014 Mar;69(3):198-202.
  64. Jurado-Gamez B, Martin-Malo A, Alvarez-Lara MA, Munoz L, Cosano A, Aljama P. Sleep disorders are underdiagnosed in patients on maintenance hemodialysis. Nephron Clin Pract. 2007;105(1):c35-c42.
  65. Roth T. Effects of excessive daytime sleepiness and fatigue on overall health and cognitive function. J Clin Psychiatry. 2015 Sep 23;76(9):e1145.
  66. Russcher M, Nagtegaal JE, Nurmohamed SA, Koch BC, van der Westerlaken MM, van Someren EJ, Baker SJ, Ter Wee PN, Gaillard CA. The effects of kidney transplantation on sleep, melatonin, circadian rhythm and quality of life in kidney transplant recipients and living donors. Nephron. 2015;129(1):6-15.
  67. Abbott SM, Reid KJ, Zee PC. Circadian Rhythm Sleep-Wake Disorders. Psychiatr Clin North Am. 2015 Dec 1;38(4):805- 823.
  68. Koch BC, van der Putten K, Van Someren EJ, Wielders JP, Ter Wee PM, Nagtegaal JE, Gaillard CA. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrol Dial Transplant. 2010 Feb;25(2):513-519.
  69. Koch BC, Nagtegaal JE, Hagen EC, Wee PM, Kerkhof GA. Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis. Sleep Med. 2010 Mar 1;11(3):242-246.
  70. Koch BC, Nagtegaal JE, Kerkhof GA, Ter Wee PM. Circadian sleep-wake rhythm disturbances in end-stage renal disease. Nat Rev Nephrol. 2009 Jul;5(7):407-416.
  71. Fleetham JA, Fleming JAE. Parasomnias. CMAJ : Canadian Medical Association Journal. 2014 May 5;186(8):E273-E280.
  72. Howell MJ. Parasomnias: An Updated Review. Neurotherapeutics. 2012 Oct 1;9(4):753-775.
  73. Bjorvatn B, Gronli J, Pallesen S. Prevalence of different parasomnias in the general population. Sleep Med. 2010 Dec 1;11(10):1031-1034.
  74. Galbiati A, Rinaldi F, Giora E, Ferini-Strambi L, Marelli S. Behavioural and Cognitive-Behavioural Treatments of Parasomnias. Behav Neurol. 2015;2015:786928.
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