Obstructive sleep apnea syndrome (OSAS) is the most common type of sleep disorder, a chronic condition characterized by frequent episodes of upper airway obstruction during sleep. There are serious complications associated with this condition, varying from different respiratory complications, neuropsychiatric disturbances to increased risk of hypertension and cardiovascular disorders. The OSAS frequently occurs in acromegaly patients with a high prevalence rate of 20 to 50%. The symptoms of sleep apnea, including snoring, tiredness, and excessive daytime sleepiness, are often reversible with an appropriate treatment strategy. We report here a middle-aged woman with excessive snoring and severe headaches caused by sleep apnea as a first sign, years before definite diagnosis of acromegaly.
Correa Cde C, Blasca WQ, Berretin-Felix G. Health promotion in obstructive sleep apnea syndrome. Int Arch Otorhinolaryngol 2015 Apr;19(2):166-170.
Archontogeorgis K, Nena E, Papanas N, Steiropoulos P. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med 2014;2014:930535.
Attal P, Chanson P. Endocrine aspects of obstructive sleep apnea. J Clin Endocrinol Metab 2010 Feb;95(2):483-495.
Wang P, Yu DJ, Feng G, Long ZH, Liu CJ, Li H, Zhao TL. Is floppy eyelid syndrome more prevalent in obstructive sleep apnea syndrome patients? J Ophthalmol 2016;2016:6980281.
Stiefel P, Sanchez-Armengol MA, Villar J, Vallejo-Vaz A, Moreno-Luna R, Capote F. Obstructive sleep apnea syndrome, vascular pathology, endothelial function and endothelial cells and circulating microparticles. Arch Med Res 2013 Aug;44(6):409-414.
Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA 2003 Oct 8;290(14):1906-1914.
Eisensehr I, Ehrenberg BL, Noachtar S, Korbett K, Byrne A, McAuley A, Palabrica T. Platelet activation, epinephrine, and blood pressure in obstructive sleep apnea syndrome. Neurology 1998 Jul;51(1):188-195.
Chanson P, Salenave S, Kamenicky P, Cazabat L, Young J. Pituitary tumours: acromegaly. Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):555-574.
Hernandez-Gordillo D, Ortega-Gomez Mdel R, Galicia-Polo L, Castorena-Maldonado A, Vergara-Lopez A, Guillen- Gonzalez MA, Torre-Bouscoulet L. Sleep apnea in patients with acromegaly. Frequency, characterization and positive pressure titration. Open Respir Med J 2012;6:28-33.
Barkan A. Acromegalic arthropathy and sleep apnea. J Endocrinol 1997 Oct;155 (Suppl 1):S41-S44; discussion S45.
Davi MV, Dalle Carbonare L, Giustina A, Ferrari M, Frigo A, Lo Cascio V, Francia G. Sleep apnoea syndrome is highly prevalent in acromegaly and only partially reversible after biochemical control of the disease. Eur J Endocrinol 2008 Nov;159(5):533-540.
Pekkarinen T, Partinen M, Pelkonen R, Iivanainen M. Sleep apnoea and daytime sleepiness in acromegaly: relationship to endocrinological factors. Clin Endocrinol (Oxf) 1987 Dec;27(6):649-654.
Perks WH, Horrocks PM, Cooper RA, Bradbury S, Allen A, Baldock N, Prowse K, van't Hoff W. Sleep apnoea in acromegaly. Br Med J 1980 Mar 29;280(6218):894-897.
Hart TB, Radow SK, Blackard WG, Tucker HS, Cooper KR. Sleep apnea in active acromegaly. Arch Intern Med 1985 May;145(5):865-866.