Indian Journal of Sleep Medicine

Register      Login

VOLUME 11 , ISSUE 2 ( April-June, 2016 ) > List of Articles


Childhood Adenoidectomy and Tonsillectomy (CHAT) Randomized Controlled Trial: Impact on the Management of Obstructive Sleep Apnea in Children

Deepak Shrivastava

Citation Information : Shrivastava D. Childhood Adenoidectomy and Tonsillectomy (CHAT) Randomized Controlled Trial: Impact on the Management of Obstructive Sleep Apnea in Children. Indian Sleep Med 2016; 11 (2):47-50.

DOI: 10.5958/0974-0155.2016.00007.3

License: NA

Published Online: 01-03-2014

Copyright Statement:  NA


The results of the first randomized controlled trial popularly known as Childhood adenoidectomy and tonsillectomy (CHAT) in otherwise healthy children of older age (five to nine years) are at best intriguing. These subjects diagnosed with mild to moderate Obstructive sleep apnea (OSA) by polysomnography (PSG) underwent the recommended first line treatment adenotonsillectomy (AT) or watchful waiting. AT provided benefit in terms of quality of life, improvement in symptoms and behavior. There is high quality evidence that AT is beneficial in terms of improvement in PSG parameters. On the contrary, high quality evidence indicates lack of benefit in objective measures of attention and neurocognitive performance compared with watchful waiting. Since its publication, CHAT database has been used for many follow up randomized trials with assessment of cardio-metabolic and demographic variables, respiratory parameters, complication rates, and weight gain.

PDF Share
  1. Gozal D, Khreindish L. Disorders of breathing during sleep. In: Chernick V, Boat TF, Wilmott RW, Bush A, eds. Kendig's Disorder of the respiratory tract inchildren. Elsevier Saunders, 2006:1046–70.
  2. Marcus CL, Brooks LJ, Draper KA, et al; American Academy of Pediatrics. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2012; 130:e714–55.
  3. CHAT Protocol V5.0 July 15, 2010
  4. Carole L. Marcus, Reneé H. Moore, Carol L. Rosen, Bruno Giordani, Susan L. Garetz, H. Gerry Taylor, Ron B. Mitchell, Raouf Amin, Eliot S. Katz, Raanan Arens, Shalini Paruthi, Hiren Muzumdar, David Gozal, Nina Hattiangadi Thomas, Janice Ware, Dean Beebe, Karen Snyder, Lisa Elden, Robert C. Sprecher, Paul Willging, Dwight Jones, John P. Bent, Timothy Hoban, Ronald D. Chervin, Susan S. Ellenberg, and Susan Redline for the Childhood Adenotonsillectomy Trial (CHAT). A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea. N Engl J Med 2013; 368:2366- 2376
  5. Redline S; Amin R; Beebe D; Chervin RD; Garetz SL; Giordani B; Marcus CL; Moore RH; Rosen CL; Arens R; Gozal D; Katz ES; Mitchell RB; Muzumdar H; Taylor HG; Thomas N; Ellenberg S. The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. SLEEP2011;34(11):1509-1517
  6. De Luca Canto G, Pacheco-Pereira C, Aydinoz S, et al. Adenotonsillectomy complications: a meta-analysis. Pediatrics2015; 136:702–18.
  7. Quante M, Wang R, Weng J, Rosen CL, Amin R, Garetz SL, Katz E, Paruthi S, Arens R, Muzumdar H, Marcus CL, Ellenberg S, Redline S; Childhood Adenotonsillectomy Trial (CHAT)..The Effect of Adenotonsillectomy for Childhood Sleep Apnea on Cardiometabolic Measures. Sleep. 2015; 38(9):1395-403.
  8. Mathias Baumert, Yvonne Pamula, James Martin, Declan Kennedy, Anand Ganesan, Muammar Kabir, Mark Kohler, Sarah A. Immanuel. The effects of adenotonsillectomy for childhood sleep apnoea on cardio respiratory control. ERJ Open Research 2016 2:00003 2016.
  9. Sofia Konstantinopoulou, Paul Gallagher, Lisa Elden, Susan L. Garetz, Ron B. Mitchell, Susan Redline, Carol L. Rosen, Eliot S. Katz, Ronald D. Chervin, Raouf Amin, Raanan Arens, Shalini Paruthi, and Carole L. Marcus. Complications of adenotonsillectomy for obstructive sleep apnea in schoolaged children. Int J Pediatr Otorhinolaryngol. 2015; 79(2):240-5.
  10. Eliot S. Katz, Renee H. Moore, Carol L. Rosen, Ron B. Mitchell, Raouf Amin, Raanan Arens, Hiren Muzumdar, Ronald D. Chervin, Carole L. Marcus, Shalini Paruthi, Paul Willging, Susan Redline. Growth After Adenotonsillectomy for Obstructive Sleep Apnea: An RCT. Pediatrics 2014; 134:2
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.