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VOLUME 11 , ISSUE 1 ( January-March, 2016 ) > List of Articles

ORIGINAL ARTICLE

Relationship of Obstructive Sleep Apnoea and Metabolic Syndrome: A Study in a South Indian Population

Harshal Satish Joshi, P. Arjun, Thomas Matthew

Keywords : Metabolic syndrome, Obstructive sleep apnoea (OSA)

Citation Information : Joshi HS, Arjun P, Matthew T. Relationship of Obstructive Sleep Apnoea and Metabolic Syndrome: A Study in a South Indian Population. Indian Sleep Med 2016; 11 (1):20-29.

DOI: 10.5958/0974-0155.2016.00005.X

License: CC BY-SA 4.0

Published Online: 01-03-2016

Copyright Statement:  Copyright © 2016; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background/Objectives: The metabolic syndrome (MS) and obstructive sleep apnoea (OSA) are associated with an increased risk for cardiovascular disease. There are a number of studies investigating the relationship of OSA and MS, but the literature from India is scarce. This study aimed to investigate the relationship of OSA and MS in Indian subjects. The aim of this study is (1) the prevalence of MS in patients with OSA, (2) whether the presence of MS correlates with the severity of OSA, and (3) the association of OSA and the components of MS. Methods: A cross-sectional, prospective study in which 110 adult patients undergoing overnight polysomnography was conductedand analysed for the presence of MS. OSA was defined as apnoea–hypopnoea index (AHI) =5 events/h. MS was diagnosed as per the definition by National Cholesterol Education Program, Adult Treatment Panel III criteria. Subjects were assessed for presence of OSA, MS, and correlation of severity of OSA with MS and association of each of the component of MS with OSA. Results: Out of the 110 subjects, 81 were found to have OSA; the remaining 29 subjects were taken as controls. Out of 81 subjects with OSA, 61 (75.30%) had MS and 9 (31.03%) out of 29 controls had MS. Interpretations/Conclusions: Subjects with OSA (1) had significantly higher prevalence of MS as compared to controls, (2) had higher systolic and diastolic blood pressures, (3) had hyperglycaemia, (4) had lower HDL cholesterol level, and (5) had differences in triglycerides and waist circumference that was not statistically significant.


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