Indian Journal of Sleep Medicine

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VOLUME 10 , ISSUE 2 ( April-June, 2015 ) > List of Articles

ORIGINAL ARTICLE

Effects of quetiapine on sleep

Umesh Kumar Vyas

Keywords : polysomnography, sleep architecture and parameters,quetiapine

Citation Information : Vyas UK. Effects of quetiapine on sleep. Indian Sleep Med 2015; 10 (2):70-73.

DOI: 10.5958/0974-0155.2015.00010.8

License: CC BY-SA 4.0

Published Online: 00-00-0000

Copyright Statement:  Copyright © 2015 Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Objectives: To determine effects of quetiapine on polysomnographicrecorded sleep architecture and parameters. Introduction and Hypothesis: Quetiapine receptor profile suggests that sleep-inducing and sleep-modifying properties may be causing changes in sleep architecture and parameter, which may have therapeutic value. Methods: A cross-sectional retrospective study conducted at the sleep center. Polysomnographic sleep records were selected and reviewed from among patients who presented over 24-months for evaluation. Twenty-one patients were selected and matched based on age, sex, body-mass index (BMI), and the presence/absence of obstructive sleep apnea (OSA) to control subjects without quetiapine. Correlation analysis was performed to assess the association of quetiapine with sleep architecture and parameters. Results: Quetiapine was not significantly associated with altered sleep efficiency, sleep latency, wake time after sleep onset, or the relative percentage of sleep stages. A notablebut not significant (p = 0.08), increase in the rapid eye movement latency was observed. Conclusions: Among the study population quetiapine was not found associated with changes in sleep architecture and parameters. Hypothesis: Use of quetiapine will be associated with shortened sleep latency (SL), increased total sleep time (TST), and increased non-rapid eye movement (NREM) stage III (most restorative sleep).


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