Indian Journal of Sleep Medicine

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VOLUME 10 , ISSUE 2 ( April-June, 2015 ) > List of Articles

REVIEW ARTICLE

Pediatric sleep apnea-need for multidisciplinary approach

Keywords : Pediatric sleep apnea, adenotonsillectomy, polysomnography, Rapid maxillary expansion

Citation Information : Pediatric sleep apnea-need for multidisciplinary approach. Indian Sleep Med 2015; 10 (2):64-69.

DOI: 10.5958/0974-0155.2015.00009.1

License: NA

Published Online: 01-03-2013

Copyright Statement:  NA


Abstract

Sleep disordered breathing (SDB) in children is a frequent disease with a prevalence varying from 1–5%. It is distinct from adults with respect to ideology, gender distribution, clinical manifestation, and treatment. Adenotonsillar enlargement is the most common cause of SDB in children. The diagnosis of SDB requires the use of special sensors such as nasal pressure transducer and esophageal pressure monitoring. The treatment of SDB in children includes amelioration of symptoms, normal cranio-facial growth and prevention of adult SDB. Adenotonsillectomy (AT) is the first line treatment of otherwise healthy children and also the initial treatment for children with multifactorial SDB. The success of AT as defined by reduction of AHI below 1 varies between 30 and 50% in various studies. A number of clinical factors such as nasal allergy, narrow and high hard palate, retro-position of mandible, enlargement of nasal inferior turbinates, high Mallampatti scale score, long face syndrome, age more than 8 years at the time of AT, and pretreatment apnea- hypopnea index (AHI) were associated with poor outcome. An impairment of nasal breathing due to adenotonsillar enlargement results in abnormal development of maxilla-mandibular skeleton resulting in narrowed upper airway. Surgery should be performed in young children as early as possible. Majority of patients have residual disease which requires additional treatment with orthodontic procedures such as rapid maxillary expansion (RME) and nasal CPAP. A multidisciplinary approach to evaluation and management of these children may lead to better treatment outcome.


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  1. Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 1999; 159: 1527–32.
  2. Suri JC, Sen MK, Adhikari T. Epidemiology of Sleep Disorders in the School Children of Delhi: A Questionnaire Based study. Indian J Sleep Med.2008; 3.2: 42–50.
  3. Ferdman Richards RM. Prolonged morbidity due to delays in the diagnosis and treatment of obstructive sleep apnea in children. Clin Pediatr (Phila). 2000; 39(2):103–8.
  4. Ali NJ, Pitson DJ, Stradling JR. Snoring, sleep disturbance, and behaviour in 4-5 year olds. Arch Dis Child. 1993 Mar;68(3):360–6.
  5. Guilleminault C, Korobkin R, Winkle R. A review of 50 children with obstructive sleep apnea syndrome. Lung. 1981;159(5):275–87.
  6. Leach J, Olson J, Hermann J, Manning S. Polysomnographic and clinical findings in children with obstructive sleep apnea. Arch Otolaryngol Head Neck Surg. 1992 Jul;118(7):741–4.
  7. Chervin RD, Dillon JE, Bassetti C, Ganoczy DA, Pituch KJ. Symptoms of sleep disorders, inattention, and hyperactivity in children. Sleep. 1997 Dec;20(12):1185– 92.
  8. Ali NJ, Pitson D, Stradling JR.Sleep disordered breathing: effects of adenotonsillectomy on behaviour and psychological functioning. Eur J Pediatr. 1996 Jan;155(1):56–62.
  9. Rhodes SK, Shimoda KC, Waid LR, O'Neil PM, Oexmann MJ, Collop NA, Willi SM.Neurocognitive deficits in morbidly obese children with obstructive sleep apnea. J Pediatr. 1995 Nov;127(5):741–4.
  10. Stradling JR, Thomas G, Warley AR, Williams P, Freeland A.Effect of adenotonsillectomy on nocturnal hypoxaemia, sleep disturbance, and symptoms in snoring children. Lancet. 1990 Feb 3;335(8684):249–53.
  11. Gozal D, Wang M, Pope DW Jr. Objective sleepiness measures in pediatric obstructive sleep apnea. Pediatrics. 2001 Sep;108(3):693–7.
  12. Sans Capdevila O, Crabtree VM, Kheirandish-Gozal L, Gozal D. Increased morning brain natriuretic peptide levels in children with nocturnal enuresis and sleep-disordered breathing: a community based study. Pediatrics 2008;121: e1208–14.
  13. Gozal D. Sleep-disordered breathing and school performance in children. Pediatrics 1998;102:616–20.
  14. Gozal D, Crabtree VM, Sans Capdevila O, Witcher LA, Kheirandish- Gozal L. C-reactive protein, obstructive sleep apnea, and cognitive dysfunction in school-aged children. Am J Respir Crit Care Med 2007; 176:188–93.
  15. Amin RS, Carroll JL, Jeffries JL, Grone C, Bean JA, Chini B, Bokulic R, Daniels SR. Twenty-four-hour ambulatory blood pressure in children with sleep-disordered breathing. Am J Respir Crit Care Med 2004;169:950–6.
  16. Marcus CL, Greene MG, Carroll JL. Blood pressure in children with obstructive sleep apnea. Am J Respir Crit Care Med 1998;157:1098–103.
  17. Tal A, Leiberman A, Margulis G, Sofer S. Ventricular dysfunction in children with obstructive sleep apnea: radionuclide assessment. Pediatr Pulmonol 1988;4:139– 43.
  18. Amin R, Somers VK, Mc Connell K, Willging P, Myer C, Sherman M, McPhail G, Morgenthal A, Fenchel M, Bean J, et al. Activity-adjusted 24-hour ambulatory blood pressure and cardiac remodeling in children with sleep disordered breathing. Hypertension 2008;51:84–91.
  19. Gozal D, Lipton AJ, Jones KL. Circulating vascular endothelial growth factor levels in patients with obstructive sleep apnea. Sleep 2002;25:59–65.
  20. Gozal D, Kheirandish-Gozal L, Serpero LD, Sans Capdevila O, Dayyat E. Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy. Circulation 2007;116:2307–14.
  21. Guilleminault C, Korobkin R, Winkle R. A review of 50 children with obstructive sleep apnea syndrome. Lung 1981;159:275.
  22. Brouillette RT, Fernbach SK, Hunt CE. Obstructive sleep apnea in infants and children. J Pediatr. 1982 Jan;100(1):31–40.
  23. Weissbluth MA, Davis AT, Poncher J et al. Signs of airway obstruction during sleep and behavioral, developmental and academic problems. J Dev Behav Pediatr 1983;4:119– 21.
  24. Everett AD, Koch WC, Saulsbury FT. Failure to thrive due to obstructive sleep apnea. Clin Pediatr 1987;26:90–92.
  25. American Thoracic Society. Standards and indication for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med1996;153:866–78.
  26. American Thoracic Society Am J Respir Crit Care Med1999 ;160:1381–7.
  27. Marcus CL, Omlin KJ, Basinki DJ, Bailey SL, Rachal AB, Von Pechmann WS, Keens TG, Ward SL.Normal polysomnographic values for children and adolescents. Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1235–9.
  28. Beck SE, Marcus SL: Pediatric polysomnography. Sleep Med Clin 2009;4:393–406.
  29. Uliel S, Tauman R, Greenfield M, Sivan Y. Normal polysomnographic respiratory values in children and adolescents. Chest 2004;125:872–8.
  30. American Academy of Sleep Medicine: ICSD-2 International Classification of Sleep Disorders, 2nd ed. Diagnostic and Coding Manual. Westchester, IL: American Academy of Sleep Medicine, 2005.
  31. Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, et al.. Rules for scoring respiratory events in sleep:update of the 2007 AASM Manual for the scoring of sleep and associated events. J Clin Sleep Med2012; 8(5):597–61.
  32. American Academy of Pediatrics. Clinical Practice Guideline: Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome. PEDIATRICS Vol. 109 No. 4 April 2002.
  33. The American Thoracic Society. Standards and Indications for Cardiopulmonary Sleep studies in Children, the official statement of the American Thoracic Society adopted by the ATS board of Directors, July 1995.Am J Respir Crit Care Med. 1996; Vol 153:866–78.
  34. David E. Tunkel. Polysomnopgraphy before Tonsillectomy in Children: Who and When? Otolaryngology – Head and Neck Surgery 2012;146:191.
  35. Chervin RD, Weatherly RA, Garetz, et al. Pediatric sleep questionnaire: prediction of sleep apnea and outcomes. Arch Otolaryngol Head Neck Surg. 2007;133:216–22.
  36. Brouillette RT, Morelli A, Leimanis A, Waters KA, Luciano R, Ducharme FM. Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea. Pediatrics. 2000;105:405–12.
  37. Rosen GM, Muckle RP, Mahowald MW, et al. Postoperative respiratory compromise in children with obstructive sleep apnea syndrome: can it be anticipated? Pediatrics 1994;93:784–8.
  38. Friedman M, Vidyasagar R, Bliznikas D, Joseph N. Does severity of obstructive sleep apnea-hypopnea syndrome predict uvulopalatopharyngoplasty outcome? Laryngoscope. 2005; 115:2109–13.
  39. Goldstein NA, Pugazhendhi V, Rao SM, et al. Clinical assessment of pediatric obstructive sleep apnea. Pediatrics 2004:114:33–43.
  40. Guilleminault C, Li KK, Quo S, et al. A prospective study of surgical outcomes in children with sleep disordered breathing. Sleep 2004;27:95–100.
  41. Guilleminault C, Huang Y, Glamann C, Li K, Chan A. Adenotonsillectomy and obstructive sleep apnea in children. Otolaryngol-Head and Neck Surg 2007 Feb;136(2): 169– 75.
  42. Brietzke SE, Gallagher D. The effectiveness of tonsillectomy and adenoidectomy in the treatment of pediatric obstructive sleep apnea/ hypopnea syndrome: a meta-analysis. Otolaryngol Head Neck Surg 2006; 134:979–84.
  43. Tauman R, Gulliver TE, Krishna J, Montgomery-Downs HE, O'Brien LM, Ivanenko A, Gozal D. persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy. J Pediatr 2006; 149:803–8.
  44. Mitchell RB, Kelly J. Outcome of adenotonsillectomy for severe obstructive sleep apnea in children. Int J Pediatr Otorhinolaryngol 2004; 68:1375–9.
  45. Suen JS, Arnold JE, Brooks LJ. Adenotonsillectomy for treatment of obstructive sleep apnea in children. Arch Otolaryngol Head Neck Surg 1995; 121:52.
  46. Friedman M, WilsonM, Lin HC, Chang HW. Updated systematic review of tonsillectomy and adenoidectomy for treatment of pediatric obstructive sleep apnea/hypopnea syndrome. Otolaryngol Head Neck Surg 2009;140:800– 8.
  47. Bhattacharjee R, Kheirandish-Gozal L, Spruyt K, Mitchell RB, Promchiarak J, Simakajornboon N, Kaditis AG, Splaingard D, Splaingard M, Brooks LJ, Marcus CL, Sin Sanghun, Arens R, Verhulst S, Gozal D. Adenotonsillectomy outcomes in children with obstructive sleep apnea in children. A multicenter retrospective study. Am J Respir Crit Care Med 2010; 182:676–83.
  48. Jagdish Chander Suri, Manas K. Sen, V.P. Venkatachalam, Shikha Bhool, Rahul Sharma, Mir Elias, Tulsi Adhikari. Outcome of adenotonsillectomy for children with sleep apnea. Sleep Medicine October 2015; 16 (10):1181–6
  49. Harvold EP, Tomar BS, Vargervik K, Chierichi G. Primate experiments on oral respiration. Am J Orthod 1981;79(4):369–72.
  50. Pirelli P, Saponara M, Guilleminault C. Rapid maxillary expansion in children with obstructive sleep apnea syndrome. Sleep. 2004;27:761–6.
  51. Guilleminault C, Li KK. Maxillomandibular expansion for the treatment of sleep-disordered breathing: preliminary result. Laryngoscope 2004;114: 893–6. 10.1097/ 00005537-200401000-00024.
  52. Guilleminault C, Monteyrol PJ, Huynh NT, Pirelli P, Quo S, Li K. Adeno-tonsillectomy and rapid maxillary distraction in pre-pubertal children, a pilot study. Sleep Breath. 2011;15:173–7.
  53. Marcus CL, Ward SL, Mallory GB, Rosen CL, Beckerman RC, Weese-Mayer DE, et al. Use of nasal continuous positive airway pressure as treatment of childhood obstructive sleep apnea. J Pediatr.1995;127:88–94.
  54. Downey R, III, Perkin RM, MacQuarrie J. Nasal continuous positive airway pressure use in children with obstructive sleep apnea younger than 2 years of age. Chest. 2000;117:1608–12.
  55. Marcus CL, Rosen G, Ward SL, Halbower AC, Sterni L, Lutz J, et al. Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea. Pediatrics. 2006;117:e442–51.
  56. Li KK, Riley RW, Guilleminault C. An unreported risk in the use of home nasal continuous positive airway pressure and home nasal ventilation in children: mid-face hypoplasia. Chest. 2000;117:916–8.
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