Indian Journal of Sleep Medicine

Register      Login

VOLUME 1 , ISSUE 4 ( October-December, 2006 ) > List of Articles


Upper Airway Resistance Syndrome (UARS)

Rayleigh Ping-Ying Chiang, Christian Guilleminault

Citation Information : Chiang RP, Guilleminault C. Upper Airway Resistance Syndrome (UARS). Indian Sleep Med 2006; 1 (4):175-182.

DOI: 10.5005/ijsm-1-4-175

License: CC BY-SA 4.0

Published Online: 01-10-2006

Copyright Statement:  Copyright © 2006; Jaypee Brothers Medical Publishers (P) Ltd.


PDF Share
  1. Gastaut H, Tassinari CA, and Duron B, Polygraphic study of diurnal and nocturnal (hypnic and respiratory) episodic manifestations of pickwick syndrome. Rev Neurol (Paris), 1965. 112: p. 568-579.
  2. Jung R and Kuhlo W, Neurophysiological studies of abnormal night sleep and the pickwickian syndrome. Prog Brain Res, 1965. 18: p. 140-159.
  3. Guilleminault C, Stoohs R, and Clerk A, A cause of excessive daytime sleepiness: the upper-airway resistance syndrome. Chest, 1993. 104: p. 781-787.
  4. Gold AR, Marcus CL, and Dipalo F, Upper airway collapsiblity during sleep in upper airway resistance syndrome. Chest, 2002. 121: p. 1531-1540.
  5. Douglas NJ, Upper airway resistance syndrome is not a distinct syndrome. Am J Respir Crit Care Med, 2000. 161: p. 1413-1416.
  6. Guilleminault C and Chowdhuri S, Uupper airway resistance syndrome is a distinct syndrome. Am J Respir Crit Care Med, 2000. 161: p. 1412-1413.
  7. AASM, International Classification of Sleep Disorders: Diagnostic & Coding Manual. 2 ed. 2005, Westchester, IL: American Academy of Sleep Medicine.
  8. Guilleminault C, Tilikan A, and D. WC., The sleep apnea syndromes. Annu Rev Med., 1976. 27: p. 465-484.
  9. Bao G and Guilleminault C, The upper airway resistance syndrome - one decade later. Curr Opin Pulm Med, 2004. 10: p. 461-467.
  10. Gold AR, Dipalo F, Gold MS, et al., The symptoms and signs of upper airway resistance syndrome: a link to the functional somatic syndromes. Chest, 2003. 123: p. 87- 95.
  11. Guilleminault C, Faul JL, and Stoohs R, Sleep-disordered breathing and hypotension. Am J Respir Crit Care Med, 2001. 164: p. 1242-1247.
  12. Guilleminault C, Kirisoglu C, Poyares A, et al., Upper Airway Resistance Syndrome: an outcome study on a retrospective cohort. J. Psych. Res., in press.
  13. Kimoff RJ, Sforza E, Champagne V, et al., Upper airway sensation in snoring and obstructive sleep apnea. Am J Respir Crit Care Med, 2001. 164: p. 250-255.
  14. Guilleminault C, Li K, Chen NH, et al., Two-point palatal discrimination in patients with upper airway resistance syndrome, obstructive sleep apnea syndrome, and normal control subjects. Chest, 2002. 122: p. 866-870.
  15. Virkkula P, Silvola J, Maasilta P, et al., Esophageal pressure monitoring in detection of sleep-disordered breathing. Laryngoscope, 2002. 112: p. 1264-1270.
  16. Norman RG, Ahmed MM, Walslebel JA, et al., Detection of respiratory events during NPSG: nasal cannula/pressure sensor versus thermistor. Sleep, 1997. 20: p. 1175-1184.
  17. Edstrom L, Larson H, and Larson L, Neurogenic effects on the palatopharyngeal muscle in patients with obstructive sleep apnea: a muscle biopsy study. J Neurol Neurosurg Psychiatry, 1992. 55: p. 916-920.
  18. Woodson BT, Garancia J, and Toohill RJ, Histopathologic changes in snoring and obstructive sleep apnea syndrome. Laryngoscope, 1991. 101: p. 1318-1332.
  19. Series F, Simoneau JA, St Pierre S, et al., Characteristics of the genioglossus and musculus uvulae in sleep apnea- hypopnea syndrome and in snorers. Am J Resp Crit Care Med, 1996. 153: p. 1870-1874.
  20. Friberg D, Answed T, and Borg K, Histological indications of a progressive snorer disease in upper airway muscle. Am J Respir Crit Care Med, 1998. 157: p. 586-593.
  21. Friberg D, Gazelius B, Holfelt T, et al., Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers. Regul Pept, 1997. 71: p. 29-36.
  22. Friberg D, Heavy snorer's disease: a progressive local neuropathy. Acta Otolaryngol., 1999. 119: p. 925-933.
  23. Nguyen ATD, Jobin V, Payne R, et al., Laryngeal and velopharyngeal sensory impairment in obstructive sleep apnea. Sleep, 2005. 28: p. 585-593.
  24. Guilleminault C, Huang YS, Kirisoglu C, et al., Is obstructive sleep apnea syndrome a neurological disorder? A continuous positive airway pressure follow-up study. Ann Neurol., 2005. [Epub ahead of print].
  25. Davenport PW, Friedman WA, Thompson FJ, et al., Respiratory-related cortical potentials evoked by inspiratory occlusion in human. J. Appl. Physiol, 1986. 60: p. 1843- 1848.
  26. Afifi L, Guilleminault C, and Colrain I, Sleep and respiratory stimulus specific dampening of cortical responsiveness in OSAS patients. Respir Physiol Neurobiol, 2003. 136: p. 221-234.
  27. Dematteis M, Lévy P, and Pépin J-L, A simple procedure for measuring pharyngeal sensation: A contribution to sleep apnoea diagnosis. Thorax, 2005. 60: p. 418-426.
  28. Chen W and Kushida CA, Nasal obstruction in sleepdisordered breathing. Otolaryngol Clin North Am, 2003. 36: p. 437-60.
  29. Gold AR, Dipalo F, Gold MS, et al., Inspiratory airflow dynamics during sleep in women with fibromyalgia. Sleep, 2004. 27: p. 459-466.
  30. Woodson BT, Expiratory pharyngeal airway obstruction during sleep: a multiple element model. Laryngoscope, 2003. 113: p. 1450-1459.
  31. Terzano MG, Parrino L, Chervin R, et al., Atlas, rules and recording techniques for the scoring of the cyclic alternating pattern (CAP) in human sleep. Sleep Med, 2001. 2: p. 537-554.
  32. ASDA, EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep, 1992. 15: p. 173-184.
  33. Zwillich C, Devlin T, White D, et al., Bradycardia during sleep apnea: characteristics and mechanism. J Clin Invest, 1982. 69: p. 1286-1292.
  34. Guilleminault C, Poyares D, Rosa A, et al., Heart rate variability, sympathetic and vagal balance, and EEG arousal in upper airway resistance and mild OSA. Sleep Med., in press.
  35. Peppard PE, Young T, Palta M, et al., Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med, 2000. 342: p. 1378-1384.
  36. Hu FB, Willett WC, Manson JE, et al., Snoring and risk of cardiovascular disease in women. J Am Coll Cardiol, 2000. 35: p. 308-313.
  37. Hung JEG, Whitford R, Parsons W, et al., The association of sleep apnea with myocardial infarction in men. Lancet, 1990. 338: p. 261-264.
  38. Wolk R, Kara T, and Somers VK, Sleep-disordered breathing and cardiovascular disease. Circulation, 2003. 108: p. 9- 12.
  39. Gami AS, Pressman G, Caples SM, et al., Association of atrial fibrillation and obstructive sleep apnea. Circulation, 2004. 110: p. 364-367.
  40. Narkiewicz K, Kato M, Phillips BG, et al., Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. Circulation, 1999. 100: p. 2332-2335.
  41. Guilleminault C and Bassiri A, Clinical features and evaluation of obstructive sleep apnea-hypopnea syndrome and the upper airway resistance syndrome. 4th ed. Principles and Practice of Sleep Medicine, ed. Kriger MH, Roth T, and Dement WC. 2005, Philadelphia: WB Saunders.
  42. Guilleminault C, Palombini L, Poyares D, et al., Chronic insomnia, post menopausal women, and SDB. Part 2: Comparison of non drug treatment trials in normal breathing and UARS post menopausal women complaining of insomnia. J. Psychosomat Res, 2002. 53: p. 617-623.
  43. Czeisler CA, Richardson GS, Coleman RM, et al., Chronotherapy: resetting the circadian clock of patients with delayed sleep phase insomnia. Sleep, 1981. 4: p. 1-21.
  44. Guilleminault C, Kirisoglu C, Palombini L, et al., Continuous NREM sleep state instability in sleepwalking. J Sleep Res, in press.
  45. Lewin DS and Pinto MD, Sleep disorders and ADHD: shared and common phenotypes. Sleep, 2004. 27: p. 188-9.
  46. Guerrero M, Lepler L, and Kristo D, The upper airway resistance syndrome masquerading as nocturnal asthma and successfully treated with an oral appliance. Sleep Breath, 2001. 5: p. 93-96.
  47. Guilleminault C, Faul JL, and Stoohs R, Sleep-disordered breathing and hypotension. Am J Respir Crit Care Med, 2001. 164: p. 1242-1247.
  48. Guilleminault C, Khramtsov A, Stoohs RA, et al., Abnormal blood pressure in prepubertal children with sleep-disordered breathing. Pediatr Res, 2004. 55: p. 76-84.
  49. Guilleminault C and Khramtsov A, Upper airway resistance syndrome in children: a clinical review. Semin Pediatr Neurol, 2001. 8: p. 207-215.
  50. Mallampati SR, Gatt SP, Gugino LD, et al., A clinical sign to predict difficult tracheal intubation: a prospective study. Can Anaesth Soc J, 1985. 32: p. 429-434.
  51. Resta O, Barbaro MPF, Bonfitto P, et al., Low sleep quality and daytime sleepiness in obese patients without obstructive sleep apnoea syndrome. J Intern Med, 2003. 253: p. 536- 543.
  52. Epstein MD, Chicoine SA, and Hanumara RC, Detection of upper airway resistance syndrome using a nasal cannula/ pressure transducer. Chest, 2000. 117: p. 1073-1077.
  53. Ayap I, Norman RG, Krieger AC, et al., Non-invasive detection of respiratory effort- related arousals (RERAs) by a nasal cannula/pressure transducer system. Sleep, 2000. 23: p. 763-771.
  54. ASDA, Atlas Task Force EEG arousals: Scoring rules and examples: A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep, 1992. 15: p. 173-184.
  55. Guilleminault C, Poyares D, Palombini L, et al., Variability of respiratory effort in relationship with sleep stages in normal controls and upper airway resistance syndrome patients. Sleep Med, 2001. 2: p. 397-406.
  56. AASM, Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep., 1999. 22: p. 667-689.
  57. Black J, Guilleminault C, Colrain I, et al., Upper airway resistance syndrome: central EEG power and changes in breathing effort. Am J Respir Crit Care Med, 2000. 162: p. 406-411.
  58. Serebrisky D, Cordero R, Mandeli, et al., Assessment of inspiratory flow limitation in children with sleep-disordered breathing by a nasal cannula pressure transducer system. Pediatric Pulmonol, 2002. 33: p. 380-387.
  59. Nanba S, Ohsaki R, and Shiomi T, Apparatus and method for electronically predicting pleural pressure from pulse wave signals. United States Patent Application, 2002. US2002/0143261: p. A1.
  60. Stoohs RA, Blum HC, Knaack L, et al., Non-invasive estimation of esophageal pressure based on inter-costal EMG monitoring. IEEE J, in press.
  61. Guilleminault C, Kim YD, Chowdhuri S, et al., Sleep and daytime sleepiness in upper airway resistance syndrome compared to obstructive sleep apnea syndrome. Eur Respir J, 2001. 17: p. 1-10.
  62. Poyares D, Guilleminault C, Rosa A, et al., Arousal, EEG spectral power and pulse transit time in UARS and mild OSAS subjects. Clin Neurophysiol, 2002. 113: p. 1598- 1606.
  63. Chervin RD, Burns JW, Subotic NS, et al., Correlates of respiratory cycle-related EEG changes in children with sleepdisordered breathing. Sleep, 2004. 27: p. 116-121.
  64. Guilleminault C, Lee JH, and Chan A, Pediatric obstructive sleep apnea syndrome. Arch Pediatr Adolesc Med, 2005. 159: p. 775-85.
  65. Lopes MC and Guilleminault C, Cyclic alternating pattern in adults with upper airway resistance syndrome. Sleep, 2005. 28(S1): p. A184.
  66. Krakow B, Melendrez D, Lee SA, et al., Refractory insomnia and sleep-disordered breathing: a pilot study. Sleep Breath, 2004. 8: p. 15-29.
  67. Yoshida K, Oral device therapy for the upper airway resistance syndrome patient. J Prodthet Dent, 2002. 87: p. 427-430.
  68. Newman JP, Clerk AA, Moore M, et al., Recognition and surgical management of the upper airway resistance syndrome. Laryngoscope, 1996. 106: p. 1089-93.
  69. Utley DS, Shin EJ, Clerk AA, et al., A Cost-Effective and Rational Surgical Approach to Patients With Snoring, Upper Airway Resistance Syndrome, or Obstructive Sleep Apnea Syndrome. Layngoscope, 1997. 107: p. 726-734.
  70. Powell N, Riley R, Guilleminault C, et al., A reversible uvulopalatal flap for snoring and sleep apnea syndrome. Sleep, 1996. 19: p. 593-599.
  71. Guilleminault C and Li KK, Maxillomandibular Expansion for the Treatment of Sleep-Disordered Breathing: Preliminary Result. Laryngoscope, 2004. 114: p. 893-896.
  72. Pirelli P, Saponara M, and Guilleminault C, Rapid maxillary expansion in children with obstructive sleep apnea syndrome. Sleep, in press.
  73. American Academy of Pediatrics - Section on Pediatric Pulmonology - Subcommittee on Obstructive Sleep Apnea Syndrome, Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics, 2002. 109: p. 704-712.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.