Indian Journal of Sleep Medicine

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VOLUME 1 , ISSUE 1 ( January-March, 2006 ) > List of Articles

ORIGINAL ARTICLE

Role of nocturnal oxygen therapy in interstitial lung disease with obstructive sleep apnoea syndrome

D. V. Shah, J. M. Joshi

Keywords : nocturnal hypoxemia, oxygen therapy, apnoea- hypopnea index (AHI), nighttime recording of respiratory variables (NTRRV)

Citation Information : Shah DV, Joshi JM. Role of nocturnal oxygen therapy in interstitial lung disease with obstructive sleep apnoea syndrome. Indian Sleep Med 2006; 1 (1):41-44.

DOI: 10.5005/ijsm-1-1-41

License: CC BY-SA 4.0

Published Online: 01-01-2006

Copyright Statement:  Copyright © 2006; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: This study was conducted to demonstrate the effects of nocturnal oxygen therapy on patients of interstitial lung disease (ILD) with associated obstructive sleep apnoea syndrome (OSAS). Methods: 12 patients (5 males, 7 females) of ILD with OSAS were included in the study. All patients had a restrictive abnormality on spirometry with a mean forced vital capacity (FVC) of 40 (+/- 14.22). The mean daytime pressures of oxygen in arterial blood (Pao2) were 71.88 (+/- 12.44) and that of carbon dioxide was 36.39 (+/- 8.27). 10 out of the 12 patients had a BMI of less then 25, while 2 patients had a BMI of 27 each. None of the patients had complaints of snoring or excessive daytime sleepiness. All patients were subjected to nighttime recording of respiratory variables (NTRRV). The first night study was done while breathing room air followed by a second night study supplemented with 2 litres of nasally administered oxygen. The effect of nasally administered oxygen on the apnoea- hypopnea index (AHI) was studied. Results: The mean AHI while breathing room air was 23.33 (+/- 6.27). On breathing oxygen at 2 litres per minute AHI dropped to 8 (+/- 8.03). In 11 out of 12 patients, the AHI decreased from a mean of 23.09 to 6.36, while the AHI in 1 patient remained unchanged. Thus overall there was a significant improvement (p<0.001) in AHI from 23.33 (+/- 6.27) to 8 (+/- 8.03) on breathing 2 litres per minute of nasally administered oxygen. Baseline oxyhaemoglobin saturation improved in all patients. Conclusion: Nocturnal oxygen therapy has a beneficial effect on the obstructive sleep apnea syndrome in selected patients of ILD and OSAS.


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  1. Perez-Padulla R, West P, Lertzman M, Kryger MH. Breathing during sleep in patients with interstitial lung disease. Am Rev Respir Dis 1985;132:224-229
  2. Bye PTP, Issa F, Berthon-Jones M, Sullivan CE. Studies of oxygenation during sleep in patients with interstitial lung disease. Am Rev Respir Dis 1984; 129: 27-32.
  3. Hira HS, Sharma RK. Study of oxygen saturation, breathing pattern and arrythmias in patients of interstitial lung diseases during sleep. Indian Journal Chest Dis Allied Sci 1997; 39:157-162.
  4. Kryger MH. Restrictive lung disorders. In WB Saunders Company. Kryger MH, Roth T, Dement W, 3 rd ed. Principles and Practice of Sleep Medicine. Philadelphia 2000: 976- 983.
  5. McNicholas WT, Carter JL, Rutherford R, Zamel J, Phillipson EA. Beneficial effect of oxygen in primary alveolar hypoventilation with central sleep apnoea. Am Rev Respir Dis 1982; 125: 773-775.
  6. Smith PL, Haponik EF, Bleecker ER. The effects of oxygen in patients with sleep apnoeas. Am Rev Respir Dis 1984; 130: 958-963.
  7. Schwab RJ, Goldberg AN, Pack AL. Sleep apnoea syndromes. In Fishman et al, 3 rd ed. Fishman's Pulmonary Diseases and Disorders. The Mc Graw-Hill Companies 1998: 1617-1638.
  8. Motta J, Guilleminault C. Effects of oxygen administered in sleep induced apnoeas. In: Guilleminault C, Dement W, Eds. Sleep Apnoea Syndromes. New York, NY: Alan & Liss; 1978: 137-144.
  9. Gold AV, Bleeker ER, Smith PL. Shifts from central and mixed sleep apnoea to obstructive apnoea resulting from low flow oxygen. Am Rev Respir Dis 1985; 132: 220-223.
  10. Bubis MJ, Anthonisen NR. Primary alveolar hypoventilation treated by administration of O2. Am Rev Respir Dis 1978; 118: 947-53.
  11. White DP. Central Sleep Apnoea. In WB Saunders Company. Kryger MH, Roth T, Dement W, 3 rd ed. Principles and Practice of Sleep Medicine. Philadelphia 2000: 827-839.
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