Indian Journal of Sleep Medicine

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VOLUME 1 , ISSUE 1 ( January-March, 2006 ) > List of Articles


Leptin, obesity and sleep disordered breathing

J. C. Suri

Citation Information : Suri JC. Leptin, obesity and sleep disordered breathing. Indian Sleep Med 2006; 1 (1):1-5.

DOI: 10.5005/ijsm-1-1-1

License: NA

Published Online: 01-01-2011

Copyright Statement:  NA


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  1. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–32
  2. Zhang F, Babinski MB, Beals JM, et al. Crystal structure of the obese protein leptin-E100. Nature 1997;387:206–9
  3. Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292–5
  4. Tartaglia L. The leptin receptor. J Biol Chem 1997;272:6093–6
  5. Flier JS, Maratos-Flier E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 1998;92:437–40
  6. Mantzoros CS. Leptin and the hypothalamus: neuroendocrine control of food intake. Mol Psychiatry 1999;4:8–12
  7. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543–6
  8. Dumbar J. C. Hu Y, Lu H, 1997. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 46, 2040- 2043
  9. Haynes W.G, Morgan D.A., Walsh S. A., Sivitz W. I, Mark A. L. 1998. Cardiovascular consequences of obesity: role of leptin. Clin Exp. Pharmacol. Physiol. 25, 65-69
  10. Tritos N, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia 1997;40:1371–9
  11. Welt, C, Chan, J, Bullen, J, et al Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004;351,987-997
  12. Fried SK, Ricci MR, Russell CD, et al. Regulation of leptin production in humans. J Nutr 2000;130:3127–31S
  13. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999;130:671–80
  14. Tankersley CG, Kleeberger S, Russ B, et al. Modified control of breathing in genetically obese (ob/ob) mice. J Appl Physiol 1996;81:716–23.
  15. Ingalls A.M., Dickie M.M., Snell G.D., 1950. Obese, a new mutation in the house mouse. J. heredity 41, 317.
  16. Tankersley C, kleeberger S., Russ B., Schwartz A. R., Smith, P. L. 1996. Modified control of breathing in genetically obese (ob/ob) mice. J appl, Physiol. 81, 716-723
  17. O'Donnell C.P., schaub C.D., Haines A. S. et al, 1999. Leptin prevents respiratory depression in obesity. Am J. Resp. Crit. Care Med. 159, 1477-1484.
  18. Tankersley CG, O'Donnell C, Daood MJ. Leptin attenuates respiratory complications associated with the obese phenotype. J Appl Physiol 1998;85:2261–9
  19. O'Donnell CP, Schaub CD, Haines AS, et al. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999;159:1477–84
  20. Mercer J. G, Moar K. M., Hoggarad N., et al. 1998. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139, 29-34.
  21. Shioda S, Funahashi H, nakajo S, Yada T, Maruta O, Nakai Y; 1998. Immunohistochemical localization of leptin receptor in the rat brain. Neurosci. Lett. 243, 41-44.
  22. Caro, J, Kolaczynski, J, Nyce, M, et al Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1997;348,159- 161.
  23. Molarius A, Seidell JC, Sans S, et al. Educational level, relative body weight, and changes in their association over 10 years : an international perspective from the WHO MONICA Project. Am J Public health 2000; 90:1260- 1268
  24. Burwell, C. S., E. D. Robin, R. D. Whaley, and A. G. Bicklemann. 1956. Extreme obesity associated with alveolar hypoventilation a Pickwickian syndrome. Am. J. Med. 21: 811-818.
  25. Zwillich, C. W., F. D. Sutton, D. J. Pierson, E. M. Creagh, and J. V. Weil. 1975. Decreased hypoxic ventilatory drive in obesity hypoventilation syndrome. Am. J. Med. 59: 343- 348
  26. MacGregor, M. I., A. J. Block, and W. C. Ball Jr.. 1970. Serious complications and sudden death in the Pickwickian syndrome. Johns Hopkins Med. J. 126: 279-295
  27. Bray, G. A. 1985. Complications of obesity. Ann. of Intern. Med. 103(6, Pt. 2):1052-1062
  28. Phipps, P, Starritt, E, Caterson, I, et al Association of serum leptin with hypoventilation in human obesity. Thorax 2002;57,75-76
  29. Janssens JP, Derivaz S, Breitenstein E, et al. Changing patterns in long-term noninvasive ventilation ; a 7- year prospective study in the Geneva Lake area. Chest 2003;123:67-79.
  30. Kessler R, Chaouat A, Schinkewitch P, et al. The obesityhypoventilation syndrome revisited: a prospective study of 34 consecutive cases. Chest 2001;120:369-376.
  31. M. Fitzpatrick. Leptin and the obesity hypoventilation syndrome: a leap of faith?. Throax 2002:57, 1-2
  32. Phillips BG, Kato M, Narkiewicz K, et al. Increases in leptin levels, sympathetic drive and weight gain in obstructive sleep apnea. Am J Physiol heart Circ Physiol 2000;279:H234-7.
  33. Shimura, R, Tatsumi, K, Nakamura, A, et al Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005;127,543-549
  34. Chin K, Shimizu K, Nakamura T, et al. Changes in intraabdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999;100:706-12.
  35. Yee BJ, Cheung U. Phipps P, Banerjee D, Piper AJ, Grunstein RR. Treatment of Obesity Hypoventilation Syndrome and Serum leptin. Respiration 2005 Sep 20;[Epub ahead of print]
  36. Polotsky V, Wilson J. Smaldone M, et al. Femal gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Crit Care Med 2001;164:1470-1475.
  37. Nowbar, S, Burkart, KM, Gonzales, R, et al Obesityassociated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med 2004;116,1- 7
  38. Schwartz MW, Seeley R. Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997;336:1802- 1811.
  39. Piper A.J., Sullivan C.E., Effects of short-term NIPPV in the treatment of patients with severe obstructive sleep apnea and hypercapnia. Chest (1994) 105 : pp 434-440
  40. Koenig S.M., Pulmonary complications of obesity. Am J Med Sci (2001) 321 : pp 249-279
  41. Weil J.V., Byrne-Quinn E., Sodal I.E., Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J Clin Invest (1971) 50 : pp 186-195
  42. Cooper K.R., Phillips B.A., Effect of short-term sleep loss on breathing. J Appl Physiol (1982) 53 : pp 855-858.
  43. The Report of an American Academy of Sleep Task Force. Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. Sleep (1999)
  44. Zwillich C.W., Sutton F.D., Pierson D.J., Decreased hypoxemic ventilatory drive in the obesity hypoventilation syndrome. Am J Med (1975) 59 : pp 343-348.
  45. Emigril C., Sobol B.J., The effects of weight reduction on pulmonary function and the sensitivity of the respiratory center in obesity. Am Rev Respir Dis (1973) 108 : pp 831- 842
  46. Garay Sm, Rapoport D., Sorkin B., Regulation of ventilation in the obstructive sleep apnea syndrome. Am Rev Respir Dis (1981) 124 : pp 451-457.
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